{"topic_id":"evidence_equine_neurologic_diet","category":"evidence","context":"---\ntopic_id: evidence_equine_neurologic_diet\ncategory: evidence\ntitle: \"Horse — neurologic disease (EPM / ataxia / motor neuron) — dietary management (Europe PMC)\"\nlang: en\nsource: \"Europe PMC REST search (europepmc.org), query '(horse OR equine) AND (neurologic OR ataxia OR EPM OR \\\"motor neuron\\\") AND (diet OR nutrition OR \\\"vitamin E\\\" OR feeding)', 6021 hits, pulled 2026-07-22\"\nsource_file: pdf-raw/evidence/europepmc_evidence_equine_neurologic_diet_2026-07-22.txt\ndate_parsed: 2026-07-22\ntokens_estimated: 260\nverification:\n  method: paraphrase\n  claims: 30\n  passed: 30\n  date: 2026-07-22\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 42461371\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Horse — neurologic disease (EPM / ataxia / motor neuron) — dietary management (Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/42461371/\"\n  retrieved: \"2026-07-22\"\n  ref: \"PMID 42461371\"\n  doc_type: \"official PDF\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Horse — neurologic disease (EPM / ataxia / motor neuron) — dietary management (Europe PMC)\nSource: Europe PMC REST search, query \"(horse OR equine) AND (neurologic OR ataxia OR EPM OR \"motor neuron\") AND (diet OR nutrition OR \"vitamin E\" OR feeding)\", 6021 hits (2026-07-22). 6 representative studies below (filtered for species + nutrition relevance).\n\n1. PMID 42461371 — *[Paraphrased derived summary — non-Open-Access source.]* A 2026 Equine Veterinary Journal study examined altered liver and small-intestine gene expression in horses with equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM)—the second most common cause of spinal ataxia in US horses; the excerpt is cut off before the diet/vitamin-E findings.\n2. PMID 40443203 — *[Paraphrased derived summary — non-Open-Access source.]* A 2025 review summarizes diseases of the nervous system of equids in Brazil, noting CNS disease was little characterized there until the 1980s and that several university diagnostic laboratories later developed; the excerpt is cut off before the specific diseases and dietary links.\n3. PMID 38205913 — Measurement of 8-hydroxy-2'-deoxyguanosine in serum and cerebrospinal fluid of horses with neuroaxonal degeneration and other causes of proprioceptive ataxia. (Journal of veterinary internal medicine, 2024). Abstract (opening): Eight-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage evaluated in human neurodegenerative disease, has potential to correlate with postmortem diagnosis of neur *[CC BY — Open Access, verbatim with attribution.]*\n4. PMID 38095342 — Clinical and histopathological features in horses with neuroaxonal degeneration: 100 cases (2017-2021). (Journal of veterinary internal medicine, 2024). Abstract (opening): Adult horses with proprioceptive ataxia and behavior changes that have histologic lesions consistent with neurodegenerative disease have been increasingly recognized. Describe the  *[CC BY — Open Access, verbatim with attribution.]*\n5. PMID 41893540 — The Dark Side of Grasslands: Endophyte Toxicosis in Horses-Exposure Risks, Health Consequences, and Management. (Toxins, 2026). Abstract (opening): Grasslands are the cornerstone of horse feeding, used for grazing and to produce roughages and their products. However, improper grassland management hides several threats for equi *[CC BY — Open Access, verbatim with attribution.]*\n6. PMID 41893656 — Gaps Between Awareness and Prevention of West Nile Virus Among Horse Owners in an Endemic Country: A Cross-Sectional Study from Romania. (Veterinary sciences, 2026). Abstract (opening): West Nile virus (WNV) circulates endemically in Romania, yet prevention of WNV infection in horses largely depends on owner-driven decisions that require accurate risk perception a *[CC BY — Open Access, verbatim with attribution.]*\n\nNote: study selection and synthesis are left to the API consumer; this topic only surfaces primary sources with verbatim abstract openings.\n\nSource text: `pdf-raw/evidence/europepmc_evidence_equine_neurologic_diet_2026-07-22.txt` (Europe PMC REST + PubMed efetch, 2026-07-22).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/38095342/\n- https://pubmed.ncbi.nlm.nih.gov/38205913/\n- https://pubmed.ncbi.nlm.nih.gov/40443203/\n- https://pubmed.ncbi.nlm.nih.gov/41893540/\n- https://pubmed.ncbi.nlm.nih.gov/41893656/\n- https://pubmed.ncbi.nlm.nih.gov/42461371/\n","sources":["Europe PMC — Horse — neurologic disease (EPM / ataxia / motor neuron) — dietary management (Europe PMC) (retrieved 2026-07-22)"],"source":{"authority":"Europe PMC","title":"Horse — neurologic disease (EPM / ataxia / motor neuron) — dietary management (Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/42461371/","retrieved":"2026-07-22","ref":"PMID 42461371","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 42461371","verification_file":"pdf-raw/evidence/europepmc_evidence_equine_neurologic_diet_2026-07-22.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 42461371","source_file":"pdf-raw/evidence/europepmc_evidence_equine_neurologic_diet_2026-07-22.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":260,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}