{"topic_id":"evidence_canine_lyme_disease","category":"evidence","context":"---\ntopic_id: evidence_canine_lyme_disease\ncategory: evidence\ntitle: \"Evidence cluster — canine Lyme borreliosis (Borrelia burgdorferi): diagnosis, treatment & prevention (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-24\"\nsource_file: pdf-raw/evidence/pubmed_evidence_canine_lyme_disease_2026-07-24.txt\ndate_parsed: 2026-07-24\ntokens_estimated: 420\nverified: true\nverification:\n  method: paraphrase\n  claims: 5\n  passed: 5\n  date: 2026-07-24\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 41808193\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — canine Lyme borreliosis (Borrelia burgdorferi): diagnosis, treatment & prevention (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41808193/\"\n  retrieved: \"2026-07-24\"\n  ref: \"PMID 41808193\"\n  doc_type: \"official PDF\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n\n# Evidence: canine Lyme borreliosis (Borrelia burgdorferi): diagnosis, treatment & prevention (peer-reviewed, Europe PMC)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-24. Query: `(\"Lyme disease\" OR \"Borrelia burgdorferi\") AND dog AND (treatment OR vaccination OR prevention OR management)`. The cluster returns **6** first-hand abstracts extracted below (verbatim sentences, each traceable by PMID).\n\n## Verified claims (verbatim, substring of saved source)\n- **PMID 41808193** — Background Both Simparica® and Simparica TRIO® chewable tablets are efficacious within 12 h against existing Ixodes scapularis infestations and within 24 h against re-infestations for 1 month. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 42150803** — *[Paraphrased derived summary — non-Open-Access source.]* Canine vector-borne diseases (CVBDs) pose a significant threat to dogs and to public health. (Source excerpt truncated at abstract opening.)\n- **PMID PPR1213835** — Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes scapularis ticks, remains a significant vector-borne illness in the United States.\n- **PMID 42115648** — *[Paraphrased derived summary — non-Open-Access source.]* Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes scapularis ticks, remains a significant vector-borne illness in the United States. (Source excerpt truncated at abstract opening.)\n- **PMID 41353540** — Background Borrelia burgdorferi, the causative agent of Lyme disease, is a zoonotic vector-borne pathogen transmitted by various Ixodes tick species. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 42137223** — A comprehensive synthesis of current evidence on surveillance, prevention and control measures for 25 selected vector-borne diseases (VBDs) affecting animals in the EU is presented here. *[CC BY — Open Access, verbatim with attribution.]*\n\n## Studies (PMID / year / journal / title)\n- **PMID 41808193 (2026, Parasites & vectors)** — Efficacy of Simparica and Simparica TRIO for the prevention of Borrelia burgdorferi by Ixodes scapularis. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 42150803 (2026, Veterinary parasitology, regional studies and reports)** — *[Paraphrased derived summary — non-Open-Access source.]* Canine vector-borne diseases (CVBDs) pose a significant threat to dogs and to public health. (Source excerpt truncated at abstract opening.)\n- **PMID PPR1213835 (2026, )** — A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi\n- **PMID 42115648 (2026, NPJ vaccines)** — *[Paraphrased derived summary — non-Open-Access source.]* Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes scapularis ticks, remains a significant vector-borne illness in the United States. (Source excerpt truncated at abstract opening.)\n- **PMID 41353540 (2025, Parasites & vectors)** — Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 42137223 (2026, EFSA journal. European Food Safety Authority)** — Knowledge mapping of risk mitigation measures against vector-borne diseases. *[CC BY — Open Access, verbatim with attribution.]*\n\nSource text: `pdf-raw/evidence/pubmed_evidence_canine_lyme_disease_2026-07-24.txt` (Europe PMC first-hand abstracts, pulled 2026-07-24).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/41353540/\n- https://pubmed.ncbi.nlm.nih.gov/41808193/\n- https://pubmed.ncbi.nlm.nih.gov/42115648/\n- https://pubmed.ncbi.nlm.nih.gov/42137223/\n- https://pubmed.ncbi.nlm.nih.gov/42150803/\n","sources":["Europe PMC — Evidence cluster — canine Lyme borreliosis (Borrelia burgdorferi): diagnosis, treatment & prevention (peer-reviewed, Europe PMC) (retrieved 2026-07-24)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — canine Lyme borreliosis (Borrelia burgdorferi): diagnosis, treatment & prevention (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41808193/","retrieved":"2026-07-24","ref":"PMID 41808193","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 41808193","verification_file":"pdf-raw/evidence/pubmed_evidence_canine_lyme_disease_2026-07-24.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 41808193","source_file":"pdf-raw/evidence/pubmed_evidence_canine_lyme_disease_2026-07-24.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":882,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}