{"topic_id":"evidence_canine_hepatic_diet","category":"evidence","context":"---\ntopic_id: evidence_canine_hepatic_diet\ncategory: evidence\ntitle: \"Canine hepatic / liver disease — diet — representative studies (Europe PMC)\"\nlang: en\nsource: \"Europe PMC REST search (europepmc.org), query 'dog hepatic disease diet', 5870 hits, pulled 2026-07-22\"\nsource_file: pdf-raw/evidence/europepmc_canine_hepatic_diet_2026-07-22.txt\ndate_parsed: 2026-07-22\ntokens_estimated: 220\nverification:\n  method: paraphrase\n  claims: 30\n  passed: 30\n  date: 2026-07-22\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 41818730\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Canine hepatic / liver disease — diet — representative studies (Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41818730/\"\n  retrieved: \"2026-07-22\"\n  ref: \"PMID 41818730\"\n  doc_type: \"official PDF\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Canine hepatic / liver disease — diet — representative studies (Europe PMC)\n\nSource: Europe PMC (Europe PubMed Central) REST search, query \"dog hepatic disease diet\", 5870 hits (2026-07-22). Each entry is a first-hand peer-reviewed study; the abstract opening is quoted verbatim from the publisher abstract. Five representative studies below.\n\n1. PMID 41818730 — Long-term safety and efficacy of oral bezafibrate use in dogs with hypertriglyceridemia. (Journal of veterinary internal medicine, 2026). Abstract (opening): Background Bezafibrate (BZF) is effective for the treatment of hypertriglyceridemia in dogs, but there is limited data on its long-term use. Hypothesis/objectives Assess the *[CC BY — Open Access, verbatim with attribution.]*\n2. PMID 41976013 — Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats. (Animals : an open access journal from MDPI, 2026). Abstract (opening): This review classifies plant-derived functional ingredients in pet food according to phytochemical groups and application forms, including direct oral supplementation and *[CC BY — Open Access, verbatim with attribution.]*\n3. PMID 41624119 — Severe hepatic lipidosis in a dog: a case report. (Veterinary research forum : an international quarterly journal, 2025). Abstract (opening): Hepatic lipidosis (fatty liver) is a rare condition in dogs, primarily caused by improper feeding and care practices. It involves the accumulation of triacylglycerols in *[CC BY — Open Access, verbatim with attribution.]*\n4. PMID 41685531 — *[Paraphrased derived summary — non-Open-Access source.]* A 3-year-old Standard Poodle fed a raw elk-meat diet developed anorexia, icterus, and markedly elevated liver enzymes; histopathology revealed pancreatic and biliary-duct Hammondia heydorni infection. (Source excerpt truncated at abstract opening.)\n5. PMID 41800300 — Case Report: long-term calcaemia management in a dog after thyroidectomy and parathyroidectomy. (Frontiers in veterinary science, 2026). Abstract (opening): This report describes a canine case of severe hypocalcaemia following the surgical removal of a thyroid lobe and the ipsilateral parathyroid glands for thyroid carcinoma. After *[CC BY — Open Access, verbatim with attribution.]*\n\nNote: study selection and synthesis are left to the API consumer; this topic only surfaces primary sources with verbatim abstract openings.\n\nSource text: `pdf-raw/evidence/europepmc_canine_hepatic_diet_2026-07-22.txt` (Europe PMC REST, 2026-07-22).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/41624119/\n- https://pubmed.ncbi.nlm.nih.gov/41685531/\n- https://pubmed.ncbi.nlm.nih.gov/41800300/\n- https://pubmed.ncbi.nlm.nih.gov/41818730/\n- https://pubmed.ncbi.nlm.nih.gov/41976013/\n","sources":["Europe PMC — Canine hepatic / liver disease — diet — representative studies (Europe PMC) (retrieved 2026-07-22)"],"source":{"authority":"Europe PMC","title":"Canine hepatic / liver disease — diet — representative studies (Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41818730/","retrieved":"2026-07-22","ref":"PMID 41818730","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 41818730","verification_file":"pdf-raw/evidence/europepmc_canine_hepatic_diet_2026-07-22.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 41818730","source_file":"pdf-raw/evidence/europepmc_canine_hepatic_diet_2026-07-22.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":220,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}