{"topic_id":"evidence_canine_cushing_diet","category":"evidence","context":"---\ntopic_id: evidence_canine_cushing_diet\ncategory: evidence\ntitle: \"Evidence cluster — dietary management of canine hyperadrenocorticism (Cushing's disease) (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-27\"\nsource_file: pdf-raw/evidence/europepmc_evidence_canine_cushing_diet_20260727.txt\ndate_parsed: 2026-07-27\ntokens_estimated: 0\nverification:\n  method: substring_match\n  claims: 2\n  passed: 2\n  date: 2026-07-27\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 41893715\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — dietary management of canine hyperadrenocorticism (Cushing's disease) (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41893715/\"\n  retrieved: \"2026-07-27\"\n  ref: \"PMID 41893715\"\n  doc_type: \"official abstract\"\n  needs_review: false\nlicense: cc_by\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: dietary management of canine hyperadrenocorticism (Cushing's disease)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-27. Query: `cushing disease dog diet`. The cluster returns **2** records in Europe PMC; 6 representative studies are extracted below. Abstract text is verbatim from source; each study is traceable by PMID.\n\n## Studies\n- **PMID 41893715 (2026, Veterinary sciences)** — Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration... Canine cognitive dysfunction (CCD) is a common age-related neurodegenerative disorder in dogs that shares several pathological and clinical features with human Alzheimer's disease (AD). In both species, β-amyloid (Aβ) accumulates within the brain parenchyma and cerebral vessel walls and is associated with synaptic loss, oxidative stress, mitochondrial dysfunction, and chronic n\n- **PMID 41053838 (2025, BMC veterinary research)** — Enterocutaneous fistula as a long-term complication of jejunostomy tube placement in a dog with hyperadrenocorticism... <h4>Background</h4>Jejunostomy tube (JT) feeding is a practical method of delivering enteral nutrition in dogs when oral, oesophageal or gastric feeding is not feasible, particularly in postoperative or critically ill patients with gastric, duodenal, proximal jejunal, or pancreatic disease. Although generally well-tolerated, JT placement is an invasive procedure associated with\n\nSource text: `pdf-raw/evidence/europepmc_evidence_canine_cushing_diet_20260727.txt` (Europe PMC first-hand abstracts, pulled 2026-07-27).\n\n## License & attribution\n\nSource abstracts / records are Open Access under Creative Commons. Each referenced\nstudy is reproduced with attribution under its specific CC license (CC BY / CC BY-NC /\nCC BY-NC-ND); the exact license variant for each reference is stated on its Europe PMC /\nPMC record. Original records:\n- https://pubmed.ncbi.nlm.nih.gov/41893715/\n- https://pubmed.ncbi.nlm.nih.gov/41053838/\n\n## Cleaning removal log (2026-08-05, codebuddy)\nPMID 41612453 — Wrong species: dental/skeletal study of wild rabbits (Oryctolagus cuniculus), not dogs.\nPMID 41254687 — Human subject: COVID-19 response study of unhoused communities in Sacramento, no dog content.\nPMID 41227294 — Human subject: osteoporosis review framed around human patients (~200M people), no dog content.\nPMID 40943282 — Off-topic/mis-clustered: generic human allergic-disease pathogenesis hypothesis; zero dog/canine content, irrelevant to Cushing diet.\n","sources":["Europe PMC — Evidence cluster — dietary management of canine hyperadrenocorticism (Cushing's disease) (peer-reviewed, Europe PMC) (retrieved 2026-07-27)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — dietary management of canine hyperadrenocorticism (Cushing's disease) (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41893715/","retrieved":"2026-07-27","ref":"PMID 41893715","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 41893715","verification_file":"pdf-raw/evidence/europepmc_evidence_canine_cushing_diet_20260727.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 41893715","source_file":"pdf-raw/evidence/europepmc_evidence_canine_cushing_diet_20260727.txt","trust":{"authority_tier":"T2","fidelity":"verbatim","license":"cc_by","display_grade":"A"},"tokens_estimated":566,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}