{"topic_id":"evidence_canine_copper_hepatopathy_diet","category":"evidence","context":"---\ntopic_id: evidence_canine_copper_hepatopathy_diet\ncategory: evidence\ntitle: \"Evidence cluster — copper-associated hepatopathy in dogs: dietary copper etiology & restriction (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-30\"\nsource_file: pdf-raw/evidence/europepmc_copper_hepatopathy_2026-07-30.txt\ndate_parsed: 2026-07-30\ntokens_estimated: 360\nverified: true\nsource_document: \"Veterinary / medical evidence (study) — PMID 41427142, 38221962\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — copper-associated hepatopathy in dogs: dietary copper etiology & restriction (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41427142/\"\n  retrieved: \"2026-07-30\"\n  ref: \"PMID 41427142; 38221962\"\n  doc_type: \"official abstract\"\n  needs_review: false\n---\n# evidence_canine_copper_hepatopathy_diet\n\nSource: first-hand peer-reviewed abstracts (Europe PMC / PubMed efetch), reproduced verbatim. Each claim below is a C1 substring of the cited source file.\n\n## Claims (C1 — verbatim substrings of source_file)\n\n1. PMID 41427142 — Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans (peer-reviewed, 2025). Abstract (opening): Copper-associated chronic hepatitis (CAH) in dogs and Wilson disease (WD) in humans are progressive hepatic disorders caused by copper accumulation. Although both diseases share similar pathomechanisms of copper-induced liver injury, they diverge in some aspects of etiology, clinical manifestations, diagnostic methods, and therapeutic strategies.\n2. PMID 38221962 — Copper metabolism and its implications for canine nutrition (peer-reviewed, 2024). Abstract (opening): Canine copper nutrition has received increased attention due to recent reports of apparent copper-associated hepatitis in the USA and European Union. In order to properly address the need to modify the U.S.\n\nSource: `pdf-raw/evidence/europepmc_copper_hepatopathy_2026-07-30.txt`\n","sources":["Europe PMC — Evidence cluster — copper-associated hepatopathy in dogs: dietary copper etiology & restriction (peer-reviewed, Europe PMC) (retrieved 2026-07-30)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — copper-associated hepatopathy in dogs: dietary copper etiology & restriction (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41427142/","retrieved":"2026-07-30","ref":"PMID 41427142","doc_type":"official PDF","source_document":"Veterinary / medical evidence (study) — PMID 41427142, 38221962","verification_file":"pdf-raw/evidence/europepmc_copper_hepatopathy_2026-07-30.txt"},"source_document":"Veterinary / medical evidence (study) — PMID 41427142, 38221962","source_file":"pdf-raw/evidence/europepmc_copper_hepatopathy_2026-07-30.txt","tokens_estimated":360,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}