{"topic_id":"evidence_canine_cognitive_dysfunction_diet","category":"evidence","context":"---\ntopic_id: evidence_canine_cognitive_dysfunction_diet\ncategory: evidence\ntitle: \"Canine cognitive dysfunction — diet / antioxidants — representative studies (Europe PMC)\"\nlang: en\nsource: \"Europe PMC REST search (europepmc.org), query 'dog cognitive dysfunction diet', 1878 hits, pulled 2026-07-21\"\nsource_file: pdf-raw/evidence/europepmc_canine_cognitive_dysfunction_diet_2026-07-21.txt\ndate_parsed: 2026-07-21\ntokens_estimated: 220\nverification:\n  method: paraphrase\n  claims: 30\n  passed: 30\n  date: 2026-07-21\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 41976093\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Canine cognitive dysfunction — diet / antioxidants — representative studies (Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41976093/\"\n  retrieved: \"2026-07-21\"\n  ref: \"PMID 41976093\"\n  doc_type: \"official PDF\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Canine cognitive dysfunction — diet / antioxidants — representative studies (Europe PMC)\n\nSource: Europe PMC (Europe PubMed Central) REST search, query \"dog cognitive dysfunction diet\", 1878 hits (2026-07-21). Each entry is a first-hand peer-reviewed study; the abstract opening is quoted verbatim from the publisher abstract. Five representative studies below.\n\n1. PMID 41976093 — Evidence-Based Clinical Management of Canine Cognitive Dysfunction Syndrome: Diagnostic Algorithms, Practical Guidelines, Critical Appraisal of Biomarkers and Translational Limitations. (Animals : an open access journal from MDPI, 2026). Abstract (opening): Canine Cognitive Dysfunction Syndrome (CCDS) is a progressive neurodegenerative disease affecting older dogs that shares many pathological mechanisms with human Alzheimer's *[CC BY — Open Access, verbatim with attribution.]*\n2. PMID 41817417 — *[Paraphrased derived summary — non-Open-Access source.]* A 2026 study in Beagles linked diet-induced dilated cardiomyopathy (DCM) to grain-free, pea-containing diets, with increased oligosaccharides proposed as a possible mechanism; the excerpt is cut off before the cognitive-performance findings (the title also references impaired cognition) are detailed.\n3. PMID 41976013 — Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats. (Animals : an open access journal from MDPI, 2026). Abstract (opening): This review classifies plant-derived functional ingredients in pet food according to phytochemical groups and application forms, including direct oral supplementation and *[CC BY — Open Access, verbatim with attribution.]*\n4. PMID 41150102 — Antioxidant Strategies for Age-Related Oxidative Damage in Dogs. (Veterinary sciences, 2025). Abstract (opening): This review examines the effects of oxidative stress on the aging process in canines, focusing on the role of antioxidants in the prevention of age-related diseases. Oxidative *[CC BY — Open Access, verbatim with attribution.]*\n5. PMID 41860870 — OLD DOG - Validating the dog as an animal model for human aging studies. (The Journal of frailty & aging, 2026). Abstract (opening): Companion dogs represent a valuable and emerging translational model for human aging, as they share the human environment, receive comparable medical care - yet have much shorter *[CC BY — Open Access, verbatim with attribution.]*\n\nNote: study selection and synthesis are left to the API consumer; this topic only surfaces primary sources with verbatim abstract openings.\n\nSource text: `pdf-raw/evidence/europepmc_canine_cognitive_dysfunction_diet_2026-07-21.txt` (Europe PMC REST, 2026-07-21).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/41150102/\n- https://pubmed.ncbi.nlm.nih.gov/41817417/\n- https://pubmed.ncbi.nlm.nih.gov/41860870/\n- https://pubmed.ncbi.nlm.nih.gov/41976013/\n- https://pubmed.ncbi.nlm.nih.gov/41976093/\n","sources":["Europe PMC — Canine cognitive dysfunction — diet / antioxidants — representative studies (Europe PMC) (retrieved 2026-07-21)"],"source":{"authority":"Europe PMC","title":"Canine cognitive dysfunction — diet / antioxidants — representative studies (Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41976093/","retrieved":"2026-07-21","ref":"PMID 41976093","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 41976093","verification_file":"pdf-raw/evidence/europepmc_canine_cognitive_dysfunction_diet_2026-07-21.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 41976093","source_file":"pdf-raw/evidence/europepmc_canine_cognitive_dysfunction_diet_2026-07-21.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":220,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}