{"topic_id":"evidence_canine_breed_large_nutrition","category":"evidence","context":"---\ntopic_id: evidence_canine_breed_large_nutrition\ncategory: evidence\ntitle: \"Evidence cluster — large / giant breed dog growth & developmental nutrition (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-22\"\nsource_file: pdf-raw/evidence/europepmc_canine_breed_large_nutrition_2026-07-22.txt\ndate_parsed: 2026-07-22\ntokens_estimated: 289\nverification:\n  method: substring_match\n  claims: 20\n  passed: 20\n  date: 2026-07-22\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 41487487\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — large / giant breed dog growth & developmental nutrition (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/41487487/\"\n  retrieved: \"2026-07-22\"\n  ref: \"PMID 41487487\"\n  doc_type: \"official PDF\"\n  needs_review: false\nlicense: cc_by\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: large / giant breed dog growth & developmental nutrition\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-22. Query: `((\"large breed\" OR \"giant breed\") AND (puppy OR growth) AND (nutrition OR diet OR calcium))`. The cluster returns **490** records in Europe PMC; 4 representative studies are extracted below. Abstract text is verbatim from source; each study is traceable by PMID.\n\n## Studies\n- **PMID 41487487 (2025, Frontiers in veterinary science)** — Exploratory analysis of nutrient composition of adult and senior dog diets.. <h4>Introduction</h4>Senior dog foods are often marketed as distinct from adult formulations, yet no specific nutrient profiles exist for this life stage.\n- **PMID 40357193 (2025, Frontiers in veterinary science)** — A proposed framework for practical multimodal management of osteoarthritis in growing dogs.. Osteoarthritis (OA) is a ubiquitous problem affecting dog joints, particularly the hip, elbow, stifle, and spine.\n- **PMID 41852679 (2026, Frontiers in nutrition)** — Accelerated early weight gain of neonatal puppies from overweight bitches compared to lean dams in spite of similar milk macronutrient composition.. <h4>Introduction</h4>Lactation is the final pathway for the maternal metabolism to influence the neonate.\n- **PMID 42245978 (2026, Frontiers in veterinary science)** — Insights into the influence of dog and guardian demographics, nutrition, and relationship on raw feeding practices.. <h4>Introduction</h4>Raw meat-based diets (RMBD) are increasingly popular among dog guardians, yet the role of personal nutrition habits and pet-guardian relationships in their adoption remains unclear.\n\nSource text: `pdf-raw/evidence/europepmc_canine_breed_large_nutrition_2026-07-22.txt` (Europe PMC first-hand abstracts, pulled 2026-07-22).\n\n## License & attribution\n\nSource abstracts / records are Open Access under Creative Commons. Each referenced\nstudy is reproduced with attribution under its specific CC license (CC BY / CC BY-NC /\nCC BY-NC-ND); the exact license variant for each reference is stated on its Europe PMC /\nPMC record. Original records:\n- https://pubmed.ncbi.nlm.nih.gov/40357193/\n- https://pubmed.ncbi.nlm.nih.gov/41487487/\n- https://pubmed.ncbi.nlm.nih.gov/41852679/\n- https://pubmed.ncbi.nlm.nih.gov/42245978/\n","sources":["Europe PMC — Evidence cluster — large / giant breed dog growth & developmental nutrition (peer-reviewed, Europe PMC) (retrieved 2026-07-22)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — large / giant breed dog growth & developmental nutrition (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/41487487/","retrieved":"2026-07-22","ref":"PMID 41487487","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 41487487","verification_file":"pdf-raw/evidence/europepmc_canine_breed_large_nutrition_2026-07-22.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 41487487","source_file":"pdf-raw/evidence/europepmc_canine_breed_large_nutrition_2026-07-22.txt","trust":{"authority_tier":"T2","fidelity":"verbatim","license":"cc_by","display_grade":"A"},"tokens_estimated":289,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}