{"topic_id":"evidence_canine_anxiety_calm_nutrition","category":"evidence","context":"---\ntopic_id: evidence_canine_anxiety_calm_nutrition\ncategory: evidence\ntitle: \"Evidence cluster — calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine) (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-22\"\nsource_file: pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt\ndate_parsed: 2026-07-22\ntokens_estimated: 406\nverification:\n  method: substring_match\n  claims: 30\n  passed: 30\n  date: 2026-07-22\n---\n\n# Evidence: calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-22. Query: `((\"calming\" OR L-theanine OR tryptophan OR \"alpha-casozepine\") AND dog AND (diet OR nutrition)) AND HAS_ABSTRACT:\"Y\"`. The cluster returns **1401** records in Europe PMC; 6 representative studies are extracted below. Abstract text is verbatim from source; each study is traceable by PMID.\n\n## Studies\n- **PMID 42004292 (2024, Veterinary evidence)** — In adult dogs is supplementary tryptophan in the diet effective in reducing signs of anxiety?. <h4>Pico question</h4>In adult dogs, is dietary supplementation with tryptophan compared with no dietary tryptophan supplement effective in reducing signs of anxiety?<h4>Clinical bottom line</h4><h4>Category of research<\n- **PMID 41976013 (2026, Animals : an open access journal from MDPI)** — Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats.. This review classifies plant-derived functional ingredients in pet food according to phytochemical groups and application forms, including direct oral supplementation and incorporation into complete diets.\n- **PMID 36978793 (2023, Antioxidants (Basel, Switzerland))** — Dietary Strategies for Relieving Stress in Pet Dogs and Cats.. A variety of physical, emotional, and mental factors can induce a stress response in pet dogs and cats.\n- **PMID 41828608 (2026, International journal of molecular sciences)** — Plasma and Brain Metabolomics Uncover Modulation of Bile Acid and Pentose Phosphate Pathways by &lt;i&gt;Melissa officinalis&lt;/i&gt; in Obese Rat Model.. While our group previously demonstrated the calming effects of <i>Melissa officinalis</i> extract (MOE) in dogs, the underlying brain-level mechanisms remain unclear.\n- **PMID 42193745 (2026, Animals : an open access journal from MDPI)** — The Digestibility of Vegan and Vegetarian Diets for Dogs and Cats.. There is growing interest in vegan and vegetarian (veg*n) diets for dogs and cats, due to factors including pet health, environmental sustainability and farmed animal welfare.\n- **PMID 41301986 (2025, Animals : an open access journal from MDPI)** — Investigation of the Digestibility, Fecal Characteristics, and Palatability of Oil Mil By-Products as a Plant-Based Protein Source in Canine Diets.. This study investigates the digestibility, fecal characteristics, and palatability of plant-based protein sources in canine diets.\n\nSource text: `pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt` (Europe PMC first-hand abstracts, pulled 2026-07-22).\n","sources":[],"tokens_estimated":406,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}