{"topic_id":"evidence_canine_anxiety_calm_nutrition","category":"evidence","context":"---\ntopic_id: evidence_canine_anxiety_calm_nutrition\ncategory: evidence\ntitle: \"Evidence cluster — calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine) (peer-reviewed, Europe PMC)\"\nlang: en\nsource: \"Europe PMC (Europe PubMed Central) REST search, first-hand peer-reviewed abstracts, pulled 2026-07-22\"\nsource_file: pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt\ndate_parsed: 2026-07-22\ntokens_estimated: 406\nverification:\n  method: paraphrase\n  claims: 5\n  passed: 5\n  date: 2026-07-22\nsource_document: \"Veterinary / medical evidence (guideline or study) — PMID 42004292\"\ncitation:\n  authority: \"Europe PMC\"\n  title: \"Evidence cluster — calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine) (peer-reviewed, Europe PMC)\"\n  url: \"https://pubmed.ncbi.nlm.nih.gov/42004292/\"\n  retrieved: \"2026-07-22\"\n  ref: \"PMID 42004292\"\n  doc_type: \"official PDF\"\n  needs_review: false\ncopyright_note: \"Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY) studies retained verbatim with attribution; non-Open-Access studies paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten).\"\nlicense: mixed\nauthority_tier: T2\nauthority_tier_basis: \"T2:oa-repo\"\nauthority_tier_date: 2026-08-04\n---\n\n# Evidence: calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine)\n\nSource: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-22. Query: `((\"calming\" OR L-theanine OR tryptophan OR \"alpha-casozepine\") AND dog AND (diet OR nutrition)) AND HAS_ABSTRACT:\"Y\"`. The cluster returns **5** records in Europe PMC; 6 representative studies are extracted below. Abstract text is verbatim from source; each study is traceable by PMID.\n\n## Studies\n- **PMID 42004292 (2024, Veterinary evidence)** — In adult dogs is supplementary tryptophan in the diet effective in reducing signs of anxiety?. <h4>Pico question</h4>In adult dogs, is dietary supplementation with tryptophan compared with no dietary tryptophan supplement effective in reducing signs of anxiety?<h4>Clinical bottom line</h4><h4>Category of research< *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 41976013 (2026, Animals : an open access journal from MDPI)** — Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats.. This review classifies plant-derived functional ingredients in pet food according to phytochemical groups and application forms, including direct oral supplementation and incorporation into complete diets. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 36978793 (2023, Antioxidants (Basel, Switzerland))** — Dietary Strategies for Relieving Stress in Pet Dogs and Cats.. A variety of physical, emotional, and mental factors can induce a stress response in pet dogs and cats. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 42193745 (2026, Animals : an open access journal from MDPI)** — The Digestibility of Vegan and Vegetarian Diets for Dogs and Cats.. There is growing interest in vegan and vegetarian (veg*n) diets for dogs and cats, due to factors including pet health, environmental sustainability and farmed animal welfare. *[CC BY — Open Access, verbatim with attribution.]*\n- **PMID 41301986 (2025, Animals : an open access journal from MDPI)** — Investigation of the Digestibility, Fecal Characteristics, and Palatability of Oil Mil By-Products as a Plant-Based Protein Source in Canine Diets.. This study investigates the digestibility, fecal characteristics, and palatability of plant-based protein sources in canine diets. *[CC BY — Open Access, verbatim with attribution.]*\n\nSource text: `pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt` (Europe PMC first-hand abstracts, pulled 2026-07-22).\n\n## License & attribution\n\nMixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC /\nCC BY-NC-ND) studies are reproduced verbatim with attribution under their specific\nCC license; non-Open-Access studies are paraphrased as derived fact summaries\n(numbers and proper nouns preserved, sentences rewritten). Original records:\n- https://pubmed.ncbi.nlm.nih.gov/42004292/\n- https://pubmed.ncbi.nlm.nih.gov/41976013/\n- https://pubmed.ncbi.nlm.nih.gov/36978793/\n- https://pubmed.ncbi.nlm.nih.gov/42193745/\n- https://pubmed.ncbi.nlm.nih.gov/41301986/\n\n## Cleaning removal log (2026-08-05, codebuddy)\nPMID 41828608 — Lab-model organism: rat metabolomics/obese-rat study; dogs only incidentally named (prior work), actual subject is rats.\n","sources":["Europe PMC — Evidence cluster — calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine) (peer-reviewed, Europe PMC) (retrieved 2026-07-22)"],"source":{"authority":"Europe PMC","title":"Evidence cluster — calming / anxiety nutrition in dogs (L-theanine, tryptophan, alpha-casozepine) (peer-reviewed, Europe PMC)","url":"https://pubmed.ncbi.nlm.nih.gov/42004292/","retrieved":"2026-07-22","ref":"PMID 42004292","doc_type":"official PDF","source_document":"Veterinary / medical evidence (guideline or study) — PMID 42004292","verification_file":"pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt"},"source_document":"Veterinary / medical evidence (guideline or study) — PMID 42004292","source_file":"pdf-raw/evidence/europepmc_canine_anxiety_calm_nutrition_2026-07-22.txt","trust":{"authority_tier":"T2","fidelity":"paraphrase","license":"mixed","display_grade":"B"},"tokens_estimated":406,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}