{"topic_id":"evidence_ade_crossref_overview","category":"evidence-ade-crossref","context":"---\ntopic_id: evidence_ade_crossref_overview\ncategory: evidence-ade-crossref\ntitle: \"Evidence ↔ ADE cross-reference overview (190 evidence + 532 ADE topics)\"\nlang: en\nsource: \"Structural cross-reference derived from web/topics/evidence/* and web/topics/ade/* (no new fetch)\"\nsource_file: \"web/topics/evidence-ade-crossref/_crossref_index.json\"\ndate_parsed: 2026-08-11\ntokens_estimated: 700\nverification:\n  method: derived_from_dataset\n  claims: 6\n  passed: 6\n  date: 2026-08-11\nderived_from_dataset: true\nsource_documents:\n  - \"web/topics/evidence-ade-crossref/_crossref_index.json\"\nsource_document: \"In-repo evidence (Europe PMC) + ADE (openFDA) topics\"\ncitation:\n  authority: \"Derived cross-reference (existing in-repo topics)\"\n  title: \"Evidence ↔ ADE cross-reference overview (190 evidence + 532 ADE topics)\"\n  url: \"\"\n  retrieved: \"2026-08-11\"\n  ref: \"web/topics/evidence-ade-crossref/_crossref_index.json\"\n  doc_type: \"derived index\"\n  needs_review: false\n---\n\n# Evidence ↔ ADE cross-reference overview (190 evidence + 532 ADE topics)\n\nA pure-structural index over the two existing in-repo layers — **evidence** (Europe PMC literature, 190 topics) and **FDA ADE** (openFDA animal-drug adverse-event reports, 532 topics). No new data was fetched; every link below points to an existing topic.\n\n## Totals\n\n- Evidence topics: 190\n- ADE topics: 532\n- Shared-drug links (an ADE drug mentioned in ≥1 evidence topic): 77\n- Evidence topics that mention an ADE drug: 79\n\n## Axis 1 — shared drug (top drugs by linked-evidence count)\n\n- `plasma` — ADE `ade_plasma_adverse_events` ↔ 13 evidence topic(s)\n- `insulin` — ADE `ade_insulin_adverse_events` ↔ 11 evidence topic(s)\n- `oxytocin` — ADE `ade_oxytocin_adverse_events` ↔ 7 evidence topic(s)\n- `meloxicam` — ADE `ade_meloxicam_adverse_events` ↔ 6 evidence topic(s)\n- `ampicillin` — ADE `ade_ampicillin_adverse_events` ↔ 5 evidence topic(s)\n- `marbofloxacin` — ADE `ade_marbofloxacin_adverse_events` ↔ 5 evidence topic(s)\n- `tiletamine` — ADE `ade_tiletamine_adverse_events` ↔ 5 evidence topic(s)\n- `zolazepam` — ADE `ade_zolazepam_adverse_events` ↔ 5 evidence topic(s)\n- `amikacin` — ADE `ade_amikacin_adverse_events` ↔ 4 evidence topic(s)\n- `enrofloxacin` — ADE `ade_enrofloxacin_adverse_events` ↔ 4 evidence topic(s)\n- `glucosamine` — ADE `ade_glucosamine_adverse_events` ↔ 4 evidence topic(s)\n- `amoxicillin` — ADE `ade_amoxicillin_adverse_events` ↔ 3 evidence topic(s)\n- `cannabidiol` — ADE `ade_cannabidiol_adverse_events` ↔ 3 evidence topic(s)\n- `doxycycline` — ADE `ade_doxycycline_adverse_events` ↔ 3 evidence topic(s)\n- `fluralaner` — ADE `ade_fluralaner_adverse_events` ↔ 3 evidence topic(s)\n\n## Axis 2 — species (evidence topics vs ADE-report-bearing drugs)\n\n- canine: 38 evidence topics ↔ 423 ADE drugs with ≥1 report\n- feline: 25 evidence topics ↔ 345 ADE drugs with ≥1 report\n- equine: 24 evidence topics ↔ 167 ADE drugs with ≥1 report\n\n## Per-drug cross-reference topics\n\nEach `evidence_ade_crossref_<drug>` topic links one ADE drug to the evidence topics mentioning it. Generated count: 77.\n\n## Honest scope note\n\nLinks are **term co-occurrence**, not clinical assertions. An evidence topic mentioning a drug name is not necessarily a study of that drug's adverse events. Verify against the linked source topics.\n","sources":["evidence-ade-crossref — Evidence ↔ ADE cross-reference overview (190 evidence + 532 ADE topics) (retrieved 2026-08-11)"],"source":{"authority":"evidence-ade-crossref","title":"Evidence ↔ ADE cross-reference overview (190 evidence + 532 ADE topics)","url":"","retrieved":"2026-08-11","ref":"","doc_type":"official source","source_document":"In-repo evidence (Europe PMC) + ADE (openFDA) topics","verification_file":"web/topics/evidence-ade-crossref/_crossref_index.json"},"source_document":"In-repo evidence (Europe PMC) + ADE (openFDA) topics","source_file":"web/topics/evidence-ade-crossref/_crossref_index.json","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":300,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}