{"topic_id":"companion_species_health_xy_sex_reversal_sry_related_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_xy_sex_reversal_sry_related_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — XY sex reversal, SRY-related (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_xy_sex_reversal_sry_related_4103.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 134\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_xy_sex_reversal_sry_related_rabbit/01_companion_species_health_xy_sex_reversal_sry_related_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — XY sex reversal, SRY-related (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001230/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — XY sex reversal, SRY-related (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: XY sex reversal, SRY-related`\n- `Summary: Song et al. (2017) \"mutated Sp1-binding sites in the 5′ flanking region of the rabbit SRY gene using the CRISPR/Cas9 system. As expected, the [resultant] SRY-Sp1 knockout rabbits had female external and internal genitalia and exhibited normal female copulatory behaviors, but they were infertile, and the adults displayed reduced follicles.\" Thus, these animals are genetically-modified organisms (GMO)`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 389099481 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2017. Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits. Oncotarget — PubMed:PMID28445127 | DOI:10.18632/oncotarget.16979 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:400044 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:480000 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — XY sex reversal, SRY-related (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — XY sex reversal, SRY-related (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/28445127/","retrieved":"","ref":"PMID 28445127","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":540,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}