{"topic_id":"companion_species_health_watanabe_heritable_hyperlipidemia_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_watanabe_heritable_hyperlipidemia_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — Watanabe heritable hyperlipidemia (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_watanabe_heritable_hyperlipidemia_1124.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_watanabe_heritable_hyperlipidemia_rabbit/01_companion_species_health_watanabe_heritable_hyperlipidemia_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — Watanabe heritable hyperlipidemia (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000499/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — Watanabe heritable hyperlipidemia (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: Watanabe heritable hyperlipidemia`\n- `Summary: In addition to naturally-occurring variants for this trait, variants have been created artificially: Genetically-modifed organism; GMO.`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1993. Is the Watanabe Heritable Hyperlipidemic Rabbit a Suitable  Experimental Model for Percutaneous Transluminal Coronary  Angioplasty in Humans? - A Light Microscopic,  Immunohistochemical and Ultrastructural Study. Journal of the American College of Cardiology — PubMed:PMID8473661 — OMIA Phene_Article / Article\n- 1993. Absence of Glomerulosclerosis in Watanabe Heritable  Hyperlipidemic Rabbits. Nephron — PubMed:PMID8502322 — OMIA Phene_Article / Article\n- 1993. Natural History of Atherosclerosis and Hyperlipidemia in  Heterozygous WHHL (WHHL-Hh) Rabbits .1. The Effects of Aging  and Gender on Plasma Lipids and Lipoproteins. Journal of Laboratory and Clinical Medicine — PubMed:PMID8426086 — OMIA Phene_Article / Article\n- 1993. Natural History of Atherosclerosis and Hyperlipidemia in  Heterozygous WHHL (WHHL-Hh) Rabbits .2. Morphologic  Evaluation of Spontaneously Occurring Aortic and Coronary  Lesions. Journal of Laboratory and Clinical Medicine — PubMed:PMID8426070 — OMIA Phene_Article / Article\n- 1993. Invivo Kinetics of Lipoprotein(a) in Homozygous Watanabe  Heritable Hyperlipidaemic Rabbits. European Journal of Clinical Investigation — PubMed:PMID8243527 — OMIA Phene_Article / Article\n- 1993. The Effects of High Levels of Vitamin-E on the Progression of  Atherosclerosis in the Watanabe Heritable Hyperlipidemic  Rabbit. Journal of Nutritional Biochemistry — OMIA Phene_Article / Article\n- 1993. Increased Platelet GPIIb/IIIa Receptor Sensitivity in  Watanabe Heritable Hyperlipidemic Rabbits. Biochemical Archives — OMIA Phene_Article / Article\n- 1993. Hyperreactivity of Aortic Smooth Muscle to Serotonin Is  Related to the Presence of Atheroma in Watanabe Heritable  Hyperlipidaemic Rabbits. Cardiovascular Research — PubMed:PMID8313424 — OMIA Phene_Article / Article\n- 1994. Whole Blood and Plasma Concentrations of 4-Hydroxy-2-Nonenal  in Watanabe Heritable Hyperlipidemic Versus New Zealand White  Rabbits. Biochemical and Biophysical Research Communications — PubMed:PMID8135808 | DOI:10.1006/bbrc.1994.1280 — OMIA Phene_Article / Article\n- 1994. In Vivo Correction of Low Density Lipoprotein Receptor  Deficiency in the Watanabe Heritable Hyperlipidemic Rabbit  with Recombinant Adenoviruses. Journal of Biological Chemistry — PubMed:PMID8175805 — OMIA Phene_Article / Article\n- 1994. Increased mRNA for CD63 antigen in atherosclerotic lesions of  Watanabe heritable hyperlipidemic rabbits. Cell Structure and Function — PubMed:PMID7820873 — OMIA Phene_Article / Article\n- 1994. Expression of mRNA for matrix gamma-carboxyglutamic acid  protein during progression of atherosclerosis in aortae of  Watanabe heritable hyperlipidemic rabbits. Journal of Biochemistry — PubMed:PMID7883748 — OMIA Phene_Article / Article\n- (60 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:143890 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606945 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1993. Is the Watanabe Heritable Hyperlipidemic Rabbit a Suitable  Experimental Model for Percutaneous Transluminal Coronary  Angioplasty in Humans? - A Light Microscopic,  Immunohistochemical and Ultrastructural Study. Journal of the American College of Cardiology — PubMed:PMID8473661 — OMIA Phene_Article / Article\n- 1993. Absence of Glomerulosclerosis in Watanabe Heritable  Hyperlipidemic Rabbits. Nephron — PubMed:PMID8502322 — OMIA Phene_Article / Article\n- 1993. Natural History of Atherosclerosis and Hyperlipidemia in  Heterozygous WHHL (WHHL-Hh) Rabbits .1. The Effects of Aging  and Gender on Plasma Lipids and Lipoproteins. Journal of Laboratory and Clinical Medicine — PubMed:PMID8426086 — OMIA Phene_Article / Article\n- 1993. Natural History of Atherosclerosis and Hyperlipidemia in  Heterozygous WHHL (WHHL-Hh) Rabbits .2. Morphologic  Evaluation of Spontaneously Occurring Aortic and Coronary  Lesions. Journal of Laboratory and Clinical Medicine — PubMed:PMID8426070 — OMIA Phene_Article / Article\n- 1993. Invivo Kinetics of Lipoprotein(a) in Homozygous Watanabe  Heritable Hyperlipidaemic Rabbits. European Journal of Clinical Investigation — PubMed:PMID8243527 — OMIA Phene_Article / Article\n- 1993. The Effects of High Levels of Vitamin-E on the Progression of  Atherosclerosis in the Watanabe Heritable Hyperlipidemic  Rabbit. Journal of Nutritional Biochemistry — OMIA Phene_Article / Article\n- 1993. Increased Platelet GPIIb/IIIa Receptor Sensitivity in  Watanabe Heritable Hyperlipidemic Rabbits. Biochemical Archives — OMIA Phene_Article / Article\n- 1993. Hyperreactivity of Aortic Smooth Muscle to Serotonin Is  Related to the Presence of Atheroma in Watanabe Heritable  Hyperlipidaemic Rabbits. Cardiovascular Research — PubMed:PMID8313424 — OMIA Phene_Article / Article\n- 1994. Whole Blood and Plasma Concentrations of 4-Hydroxy-2-Nonenal  in Watanabe Heritable Hyperlipidemic Versus New Zealand White  Rabbits. Biochemical and Biophysical Research Communications — PubMed:PMID8135808 | DOI:10.1006/bbrc.1994.1280 — OMIA Phene_Article / Article\n- 1994. In Vivo Correction of Low Density Lipoprotein Receptor  Deficiency in the Watanabe Heritable Hyperlipidemic Rabbit  with Recombinant Adenoviruses. Journal of Biological Chemistry — PubMed:PMID8175805 — OMIA Phene_Article / Article\n- 1994. Increased mRNA for CD63 antigen in atherosclerotic lesions of  Watanabe heritable hyperlipidemic rabbits. Cell Structure and Function — PubMed:PMID7820873 — OMIA Phene_Article / Article\n- 1994. Expression of mRNA for matrix gamma-carboxyglutamic acid  protein during progression of atherosclerosis in aortae of  Watanabe heritable hyperlipidemic rabbits. Journal of Biochemistry — PubMed:PMID7883748 — OMIA Phene_Article / Article\n- (60 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:143890 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606945 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — Watanabe heritable hyperlipidemia (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — Watanabe heritable hyperlipidemia (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/8473661/","retrieved":"","ref":"PMID 8473661","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1469,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}