{"topic_id":"companion_species_health_pelger_huet_anomaly_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_pelger_huet_anomaly_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — Pelger-Huet anomaly (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_pelger_huet_anomaly_1423.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 113\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_pelger_huet_anomaly_rabbit/01_companion_species_health_pelger_huet_anomaly_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — Pelger-Huet anomaly (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000783/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — Pelger-Huet anomaly (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: Pelger-Huet anomaly`\n- `Mode of inheritance: Undritz (1939) and Nachsteim (1950) presented evidence of single-locus inheritance, with heterozygotes showing the disorder and homozygotes showing an extreme form of the disorder, including chondrodysplasia, that results in neonatal death in almost all cases.`\n- `Summary: See Robinson (1958, pp. 354-355).`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: Pg (no structured Phene_Gene link)\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1977. [Studies on the frequency of the Pelger anomaly in the domestic rabbit population]. Zentralbl Veterinarmed A — PubMed:PMID407754 — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 1950. The Pelger-anomaly in man and rabbit; a mendelian character of the nuclei of the leucocytes. J Hered — PubMed:PMID15436969 | DOI:10.1093/oxfordjournals.jhered.a106108 — OMIA Phene_Article / Article\n- 1952. Beitrage zur Morphologic und Gtnetik der Pelger-Anomalie bei Mensch und Kaninchen [Morphology and genetics of the Pelger anomaly in man and the rabbit]. Zeitschrift fur menschliche Vererbungs- und Konstitutionslehre — OMIA Phene_Article / Article\n- 1939. Das Pelger-Huetsche Blutbild beim Tier und seine Bedeutung fiir die Entwicklungsgeschichte des Blutes. Schweizerische medizinische Wochenschrift — OMIA Phene_Article / Article\n- 1943. Das ausschliessliche Vorkommen reifer rundkerniger Leukozyten bei der reingezüchteten Pelger−Huëtschen Anomalie des Kaninchens und die Bedeutung der Pelger−Leukozyten in der vergleichenden Hämatologie. Folia Haemat. — OMIA Phene_Article / Article\n- 1949. Die Pelger-Anomalie der Leukocyten und die pathologische Anatomie des neugeborenen homozygoten Pelger-Kaninchens. Zeitschrift fur menschliche Vererbungs- und Konstitutionslehre — OMIA Phene_Article / Article\n- 2003. Congenital abnormalities reported in Pelger-Huët homozygosity as compared to Greenberg/HEM dysplasia: highly variable expression of allelic phenotypes. J Med Genet — PubMed:PMID14684694 | DOI:10.1136/jmg.40.12.937 — OMIA Phene_Article / Article\n- 1964. [On the activity of neutrophilic alkaline phosphatase with Pelger-Huet anomaly in rabbits]. Patol Pol — PubMed:PMID14241274 — OMIA Phene_Article / Article\n- 1953. [Effect of colchicine on the white blood picture of Pelger and non-Pelger rabbits]. Acta Haematol — PubMed:PMID13091700 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:169400 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — Pelger-Huet anomaly (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — Pelger-Huet anomaly (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/407754/","retrieved":"","ref":"PMID 407754","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":794,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}