{"topic_id":"companion_species_health_omia_3485_ferret","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_omia_3485_ferret\ncategory: companion-species-health\ntitle: \"Ferret — Cystic fibrosis (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/ferret_omia_3485_3485.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_omia_3485_ferret/01_companion_species_health_omia_3485_ferret.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Ferret — Cystic fibrosis (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001794/9669/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Ferret — Cystic fibrosis (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Mustela putorius furo (ferret)`\n- `Disorder: `\n- `Summary: Genetically-modifed organism; GMO.`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: ABCC7 (Entrez Gene ID 389841195) — OMIA Phene_Gene / GeneSynonym\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2008. Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest — PubMed:PMID18324338 | DOI:10.1172/JCI34599 — OMIA Phene_Article / Article\n- 2010. Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest — PubMed:PMID20739752 | DOI:10.1172/JCI43052 — OMIA Phene_Article / Article\n- 2010. Transgenic animals may help resolve a sticky situation in cystic fibrosis. J Clin Invest — PubMed:PMID20739746 | DOI:10.1172/JCI44235 — OMIA Phene_Article / Article\n- 2011. Comparative biology of cystic fibrosis animal models. Methods Mol Biol — PubMed:PMID21547741 | DOI:10.1007/978-1-61779-120-8_19 — OMIA Phene_Article / Article\n- 2011. New animal models of cystic fibrosis: what are they teaching us?. Curr Opin Pulm Med — PubMed:PMID21857224 | DOI:10.1097/MCP.0b013e32834b14c9 — OMIA Phene_Article / Article\n- 2012. Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. J Clin Invest — PubMed:PMID22996690 | DOI:10.1172/JCI60610 — OMIA Phene_Article / Article\n- 2003. Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer. Reprod Biol Endocrinol — PubMed:PMID14613541 | DOI:10.1186/1477-7827-1-83 — OMIA Phene_Article / Article\n- 2013. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol — PubMed:PMID23782101 | DOI:10.1165/rcmb.2012-0433OC — OMIA Phene_Article / Article\n- 2019. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis. Sci Transl Med — PubMed:PMID30918114 | DOI:10.1126/scitranslmed.aau7531 — OMIA Phene_Article / Article\n- 2020. Animal models for cystic fibrosis: A systematic search and mapping review of the literature - Part 1: genetic models. Lab Anim — PubMed:PMID31411127 | DOI:10.1177/0023677219868502 — OMIA Phene_Article / Article\n- 2022. Recombinant adeno-associated virus-mediated editing of the G551D cystic fibrosis transmembrane conductance regulator mutation in ferret airway basal cells. Hum Gene Ther — PubMed:PMID35686451 | DOI:10.1089/hum.2022.036 — OMIA Phene_Article / Article\n- 2023. Genome editing in ferret airway epithelia mediated by CRISPR/nucleases delivered with amphiphilic shuttle peptides. Hum Gene Ther — PubMed:PMID37335046 | DOI:10.1089/hum.2023.016 — OMIA Phene_Article / Article\n- (16 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:219700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:602421 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Ferret — Cystic fibrosis (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Ferret — Cystic fibrosis (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/18324338/","retrieved":"","ref":"PMID 18324338","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":838,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}