{"topic_id":"companion_species_health_omia_3236_hamster","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_omia_3236_hamster\ncategory: companion-species-health\ntitle: \"Hamster — Duper (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/hamster_omia_3236_3236.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 116\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_omia_3236_hamster/01_companion_species_health_omia_3236_hamster.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Hamster — Duper (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001643/10036/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Hamster — Duper (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Mesocricetus auratus / Phodopus spp. (hamster)`\n- `Disorder: `\n- `Summary: Lee et al. (2022): \"The duper mutation is a recessive mutation that shortens the period length of the circadian rhythm in Syrian hamsters. These animals show a large phase shift when responding to light pulses. ... we identified duper as an early nonsense allele of Cryptochrome 1 (Cry1) leading to a short, unstable protein ...\"`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 392717204 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2011. Duper: a mutation that shortens hamster circadian period. J Biol Rhythms — PubMed:PMID21775287 | DOI:10.1177/0748730411411569 — OMIA Phene_Article / Article\n- 2011. Effects of the duper mutation on circadian responses to light. J Biol Rhythms — PubMed:PMID21775288 | DOI:10.1177/0748730411411570 — OMIA Phene_Article / Article\n- 2022. duper is a null mutation of cryptochrome 1 in Syrian hamsters. Proc Natl Acad Sci U S A — PubMed:PMID35471909 | DOI:10.1073/pnas.2123560119 — OMIA Phene_Article / Article\n- 2023. Adult neurogenesis is altered by circadian phase shifts and the duper mutation in female Syrian hamsters. eNeuro — PubMed:PMID36878716 | DOI:10.1523/ENEURO.0359-22.2023 — OMIA Phene_Article / Article\n- 2024. Neuroendocrine effects of the duper mutation in Syrian hamsters: a role for Cryptochrome 1. Front Physiol — PubMed:PMID38444761 | DOI:10.3389/fphys.2024.1351682 — OMIA Phene_Article / Article\n","sources":["companion-species-health — Hamster — Duper (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Hamster — Duper (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/21775287/","retrieved":"","ref":"PMID 21775287","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":591,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}