{"topic_id":"companion_species_health_maxillary_brachygnathism_congenital_malocclusion_mandibular__rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_maxillary_brachygnathism_congenital_malocclusion_mandibular__rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_maxillary_brachygnathism_congenital_malocclusion_mandibular__2155.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 247\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_maxillary_brachygnathism_congenital_malocclusion_mandibular__rabbit/01_companion_species_health_maxillary_brachygnathism_congenital_malocclusion_mandibular__rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000149/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite`\n- `Mode of inheritance: Nachtheim (1937) suggested a recessive mode of inheritance. Huang et al. (1981) proposed a &quot;simple autosomal recessive inheritance with incomplete penetrance for this condition&quot;. Korn et al. (2016) estimated heritability to be 25%.`\n- `Summary: Disproportions in jaw length between upper and lower jaw result in teeth that are not positioned correctly and to dental malocclusion. Brachygnathia superior is observed in rabbits, most frequently in dwarf breeds.`\n- `Clin feat: In rabbits, teeth grow throughout their life. Rabbits with brachygnathia superior can have severely overgrown teeth due to abnormal wear. This can result in difficulties to feed and groom and associated severe health problems (Harcourt-Brown 1997, 2009). Affected animals require regular veterinary treatment.`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1974. Inheritance of brachygnathia superior in rabbits. Zeitschrift fur Tierzuchtung und Zuchtungsbiologie — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 2016. Genetic and environmental factors influencing tooth and jaw malformations in rabbits. Vet Rec — PubMed:PMID26908159 | DOI:10.1136/vr.103293 — OMIA Phene_Article / Article\n- 1937. Erbpathologische Untersuchungen am Kaninchen [Investigation of inherited defects in rabbits]. Z. indo Abst. u. Vererbgs — DOI:10.1007/BF01847500 — OMIA Phene_Article / Article\n- 2016. Breeding for good dental and oral health in rabbits. [Comment on Genetic and environmental factors influencing tooth and jaw malformations in rabbits; Vet Rec. 2016 Apr 2;178(14):341]. Vet Rec — PubMed:PMID27034298 | DOI:10.1136/vr.i1808 — OMIA Phene_Article / Article\n- 1981. Mandibular prognathism in the rabbit: discrimination between single-locus and multifactorial models of inheritance. J Hered — PubMed:PMID7288146 | DOI:10.1093/oxfordjournals.jhered.a109507 — OMIA Phene_Article / Article\n- 1971. Mandibular prognathism in the rabbit. Genetic studies. J Hered — PubMed:PMID5094712 | DOI:10.1093/oxfordjournals.jhered.a108111 — OMIA Phene_Article / Article\n- 1967. J Hered — DOI:10.1093/oxfordjournals.jhered.a107602 — OMIA Phene_Article / Article\n- 1997. Diagnosis, treatment and prognosis of dental disease in pet rabbits. In Practice — DOI:10.1136/inpract.19.8.407 — OMIA Phene_Article / Article\n- 2009. Dental disease in pet rabbits. In Practice — DOI:10.1136/inpract.31.8.370 — OMIA Phene_Article / Article\n- 2021. Exceptional changes in skeletal anatomy under domestication: The case of brachycephaly. Integr Org Biol — PubMed:PMID34409262 | DOI:10.1093/iob/obab023 — OMIA Phene_Article / Article\n- 2025. Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs. Anat Rec (Hoboken) — PubMed:PMID41431133 | DOI:10.1002/ar.70123 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1974. Inheritance of brachygnathia superior in rabbits. Zeitschrift fur Tierzuchtung und Zuchtungsbiologie — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 2016. Genetic and environmental factors influencing tooth and jaw malformations in rabbits. Vet Rec — PubMed:PMID26908159 | DOI:10.1136/vr.103293 — OMIA Phene_Article / Article\n- 1937. Erbpathologische Untersuchungen am Kaninchen [Investigation of inherited defects in rabbits]. Z. indo Abst. u. Vererbgs — DOI:10.1007/BF01847500 — OMIA Phene_Article / Article\n- 2016. Breeding for good dental and oral health in rabbits. [Comment on Genetic and environmental factors influencing tooth and jaw malformations in rabbits; Vet Rec. 2016 Apr 2;178(14):341]. Vet Rec — PubMed:PMID27034298 | DOI:10.1136/vr.i1808 — OMIA Phene_Article / Article\n- 1981. Mandibular prognathism in the rabbit: discrimination between single-locus and multifactorial models of inheritance. J Hered — PubMed:PMID7288146 | DOI:10.1093/oxfordjournals.jhered.a109507 — OMIA Phene_Article / Article\n- 1971. Mandibular prognathism in the rabbit. Genetic studies. J Hered — PubMed:PMID5094712 | DOI:10.1093/oxfordjournals.jhered.a108111 — OMIA Phene_Article / Article\n- 1967. J Hered — DOI:10.1093/oxfordjournals.jhered.a107602 — OMIA Phene_Article / Article\n- 1997. Diagnosis, treatment and prognosis of dental disease in pet rabbits. In Practice — DOI:10.1136/inpract.19.8.407 — OMIA Phene_Article / Article\n- 2009. Dental disease in pet rabbits. In Practice — DOI:10.1136/inpract.31.8.370 — OMIA Phene_Article / Article\n- 2021. Exceptional changes in skeletal anatomy under domestication: The case of brachycephaly. Integr Org Biol — PubMed:PMID34409262 | DOI:10.1093/iob/obab023 — OMIA Phene_Article / Article\n- 2025. Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs. Anat Rec (Hoboken) — PubMed:PMID41431133 | DOI:10.1002/ar.70123 — OMIA Phene_Article / Article\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — maxillary brachygnathism, congenital malocclusion, mandibular prognathism, crossbite (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/26908159/","retrieved":"","ref":"PMID 26908159","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1238,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}