{"topic_id":"companion_species_health_hypoadrenocorticism_dog","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_hypoadrenocorticism_dog\ncategory: companion-species-health\ntitle: \"Dog (Canis lupus familiaris) — Hypoadrenocorticism (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/dog_hypoadrenocorticism_886.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_hypoadrenocorticism_dog/01_companion_species_health_hypoadrenocorticism_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Dog (Canis lupus familiaris) — Hypoadrenocorticism (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000519/9615/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Dog (Canis lupus familiaris) — Hypoadrenocorticism (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Dog (Canis lupus familiaris)`\n- `Disorder: Hypoadrenocorticism`\n- `Summary: See also OMIA:003051-9615 : Addison’s disease and multiple autoimmune syndrome, RESF1-related in Canis lupus familiaris (dog)`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1991. Primary Adrenocortical Insufficiency in the Dog, Addisons  Disease - A Case Report. Praktische Tierarzt — OMIA Phene_Article / Article\n- 1993. Treatment of Hypoadrenocorticism in Dogs. Journal of the American Veterinary Medical Association — PubMed:PMID8496071 — OMIA Phene_Article / Article\n- 1994. Diagnosis and Management of Primary Spontaneous  Hypoadrenocorticism (Addison's Disease) in Dogs. Seminars in Veterinary Medicine and Surgery - Small Animal — PubMed:PMID7938935 — OMIA Phene_Article / Article\n- 1994. Preservative effect of aprotinin on canine plasma  immunoreactive adrenocorticotropin concentrations. Domestic Animal Endocrinology — PubMed:PMID7530181 — OMIA Phene_Article / Article\n- 1994. Pituitary gland changes in canine hypoadrenocorticism: A  functional and immunocytochemical study. Journal of Comparative Pathology — PubMed:PMID7836570 — OMIA Phene_Article / Article\n- 1994. Desoxycorticosterone pivalate in the management of canine primary hypoadrenocorticism. Journal of the South African Veterinary Association - Tydskrif  Van Die Suid - Afrikaanse Veterinere Vereniging — OMIA Phene_Article / Article\n- 1995. The most common causes of hyperkalaemia in the dog are  hypoadrenocorticism (Addison's disease), acute renal failure,  and urethral obstruction. Journal of Small Animal Practice — PubMed:PMID7723288 — OMIA Phene_Article / Article\n- 1995. Concurrent hypoadrenocorticism and hypoalbuminemia in dogs. Journal of the American Animal Hospital Association — PubMed:PMID7552662 — OMIA Phene_Article / Article\n- 1996. Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism - 225 cases (1979-1993). Journal of the American Veterinary Medical Association — PubMed:PMID8682712 — OMIA Phene_Article / Article\n- 1996. Atypical addisons disease in the dog - a retrospective survey of 14 cases. Journal of the American Animal Hospital Association — PubMed:PMID8680923 — OMIA Phene_Article / Article\n- 1996. Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs. Journal of Small Animal Practice — PubMed:PMID8805097 — OMIA Phene_Article / Article\n- 1996. Glucocorticoid deficient hypoadrenocorticism in dogs - 18 cases (1986-1995). Journal of the American Veterinary Medical Association — PubMed:PMID8960190 — OMIA Phene_Article / Article\n- (64 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:240200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:240300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1991. Primary Adrenocortical Insufficiency in the Dog, Addisons  Disease - A Case Report. Praktische Tierarzt — OMIA Phene_Article / Article\n- 1993. Treatment of Hypoadrenocorticism in Dogs. Journal of the American Veterinary Medical Association — PubMed:PMID8496071 — OMIA Phene_Article / Article\n- 1994. Diagnosis and Management of Primary Spontaneous  Hypoadrenocorticism (Addison's Disease) in Dogs. Seminars in Veterinary Medicine and Surgery - Small Animal — PubMed:PMID7938935 — OMIA Phene_Article / Article\n- 1994. Preservative effect of aprotinin on canine plasma  immunoreactive adrenocorticotropin concentrations. Domestic Animal Endocrinology — PubMed:PMID7530181 — OMIA Phene_Article / Article\n- 1994. Pituitary gland changes in canine hypoadrenocorticism: A  functional and immunocytochemical study. Journal of Comparative Pathology — PubMed:PMID7836570 — OMIA Phene_Article / Article\n- 1994. Desoxycorticosterone pivalate in the management of canine primary hypoadrenocorticism. Journal of the South African Veterinary Association - Tydskrif  Van Die Suid - Afrikaanse Veterinere Vereniging — OMIA Phene_Article / Article\n- 1995. The most common causes of hyperkalaemia in the dog are  hypoadrenocorticism (Addison's disease), acute renal failure,  and urethral obstruction. Journal of Small Animal Practice — PubMed:PMID7723288 — OMIA Phene_Article / Article\n- 1995. Concurrent hypoadrenocorticism and hypoalbuminemia in dogs. Journal of the American Animal Hospital Association — PubMed:PMID7552662 — OMIA Phene_Article / Article\n- 1996. Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism - 225 cases (1979-1993). Journal of the American Veterinary Medical Association — PubMed:PMID8682712 — OMIA Phene_Article / Article\n- 1996. Atypical addisons disease in the dog - a retrospective survey of 14 cases. Journal of the American Animal Hospital Association — PubMed:PMID8680923 — OMIA Phene_Article / Article\n- 1996. Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs. Journal of Small Animal Practice — PubMed:PMID8805097 — OMIA Phene_Article / Article\n- 1996. Glucocorticoid deficient hypoadrenocorticism in dogs - 18 cases (1986-1995). Journal of the American Veterinary Medical Association — PubMed:PMID8960190 — OMIA Phene_Article / Article\n- (64 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:240200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:240300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Dog (Canis lupus familiaris) — Hypoadrenocorticism (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Dog (Canis lupus familiaris) — Hypoadrenocorticism (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/8496071/","retrieved":"","ref":"PMID 8496071","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1349,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}