{"topic_id":"companion_species_health_haemophilia_a_cat","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_haemophilia_a_cat\ncategory: companion-species-health\ntitle: \"Cat (Felis catus) — Haemophilia A (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/cat_haemophilia_a_55.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 111\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_haemophilia_a_cat/01_companion_species_health_haemophilia_a_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Cat (Felis catus) — Haemophilia A (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA000437/9685/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Cat (Felis catus) — Haemophilia A (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Cat (Felis catus)`\n- `Disorder: Haemophilia A`\n- `Clin feat: Beetz et al. (2024) reported a 3-month-old domestic shorthair tomcat with alternating lameness, fever and inappetence: \"Coagulation tests revealed an isolated prolonged activated partial thromboplastin time (aPTT). Activity of factor VIII was 5% (reference range: 70–125%), of factor IX 55% (80–130%), and of factor XII 73% (50–140%).\"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398298973 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Beetz et al. (2024) reported a suspected splice variant in intron 19 of the <em>F8</em> gene (c.6073+2 T&gt;C, omia.variant:1767) as likely causal variant in a 3-month-old domestic shorthair tomcat with haemophilia A.\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1990. A combined deficiency of Factor-VIII and contact activation defect in a family of cats. British Veterinary Journal — PubMed:PMID2306600 | DOI:10.1016/0007-1935(90)90073-C — OMIA Phene_Article / Article\n- 1988. Inherited coagulation disorders. Vet Clin North Am Small Anim Pract — PubMed:PMID3282382 | DOI:10.1016/s0195-5616(88)50018-9 — OMIA Phene_Article / Article\n- 1978. Hemophilia A in three unrelated cats. J Am Vet Med Assoc — PubMed:PMID627514 — OMIA Phene_Article / Article\n- 1982. An effective mass-screening program for animal models of the inherited bleeding disorders. Prog Clin Biol Res — PubMed:PMID6981819 — OMIA Phene_Article / Article\n- 2024. Hämophilie A bei einem Kater mit wechselnden Lahmheiten [Hemophilia A in a male cat with intermittent lameness]. Tierarztl Prax Ausg K Kleintiere Heimtiere — PubMed:PMID39447565 | DOI:10.1055/a-2404-1427 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:306700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300841 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Cat (Felis catus) — Haemophilia A (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Cat (Felis catus) — Haemophilia A (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/2306600/","retrieved":"","ref":"PMID 2306600","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":692,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}