{"topic_id":"companion_species_health_gist_dog","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_gist_dog\ncategory: companion-species-health\ntitle: \"Dog (Canis lupus familiaris) — GIST (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/dog_gist_2989.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_gist_dog/01_companion_species_health_gist_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Dog (Canis lupus familiaris) — GIST (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001516/9615/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Dog (Canis lupus familiaris) — GIST (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Dog (Canis lupus familiaris)`\n- `Disorder: GIST`\n- `Summary: IT IS IMPORTANT TO NOTE THAT THESE ARE UNDERSTOOD TO BE A SOMATIC MUTATIONS, WHICH MEANS THAT THE VARIANTS ARE NOT INHERITED AND WILL NOT BE PASSED ON TO OFFSPRING.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: c-KIT (Entrez Gene ID 403811) — OMIA Phene_Gene / GeneSynonym\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2010. Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11. BMC Cancer — PubMed:PMID20950418 | DOI:10.1186/1471-2407-10-559 — OMIA Phene_Article / Article\n- 2016. Analysis of c-KIT exon 11 mutations in canine gastrointestinal stromal tumours. Vet J — PubMed:PMID26631948 | DOI:10.1016/j.tvjl.2015.10.051 — OMIA Phene_Article / Article\n- 2022. Gastrointestinal stromal tumor (GIST) presenting as a multilocular cystic intra-abdominal mass in a dog. BMC Vet Res — PubMed:PMID36435800 | DOI:10.1186/s12917-022-03504-0 — OMIA Phene_Article / Article\n- 2023. CT features of gastrointestinal spindle cell, epithelial, and round cell tumors in 41 dogs. Vet Radiol Ultrasound — PubMed:PMID36382620 | DOI:10.1111/vru.13188 — OMIA Phene_Article / Article\n- 2023. Canine gastrointestinal stromal tumours treated with surgery and imatinib mesylate: three cases (2018-2020). J Small Anim Pract — PubMed:PMID36335646 | DOI:10.1111/jsap.13572 — OMIA Phene_Article / Article\n- 2025. A canine c-kit novel mutation isolated from a gastrointestinal stromal tumor (GIST) retains the ability to form dimers but lacks autophosphorylation. Animals (Basel) — PubMed:PMID40427321 | DOI:10.3390/ani15101444 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:606764 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:164920 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Dog (Canis lupus familiaris) — GIST (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Dog (Canis lupus familiaris) — GIST (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/20950418/","retrieved":"","ref":"PMID 20950418","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":672,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}