{"topic_id":"companion_species_health_diabetes_mellitus_dog","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_diabetes_mellitus_dog\ncategory: companion-species-health\ntitle: \"Dog (Canis lupus familiaris) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/dog_diabetes_mellitus_527.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 209\nverification:\n method: substring_match\n claims: 4\n passed: 4\n date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_diabetes_mellitus_dog/01_companion_species_health_diabetes_mellitus_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n title: \"Dog (Canis lupus familiaris) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)\"\n url: \"https://omia.org/OMIA000279/9615/\"\n retrieved: \"2026-08-24\"\n ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n needs_review: false\n\nverification_derived:\n method: derived_from_dataset\n source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n method: derived_from_dataset\n source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Dog (Canis lupus familiaris) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Dog (Canis lupus familiaris)`\n- `Disorder: Diabetes mellitus`\n- `Mode of inheritance: In a textbook example of investigating the heritability and mode of inheritance of a disorder, Cai et al. (2019) estimated heritability of diabetes mellitus (DM) in American Eskimo Dogs (AED) to be 0.62 (95% posterior interval 0.01-0.99) and the mode of inheritance to be "polygenic, with no evidence for a single gene of large effect." The low precision of the heritability estimate is due to the relatively small numbers of animals available, namely "71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM".`\n- `Control: As concluded by Cai et al. (2019), \"Breeders could successfully implement a breeding program to decrease the incidence of DM in AED.\"`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- 1960. The interrelationship between diabetes mellitus, obesity and pyometra in the dog. American Journal of Veterinary Research VL — OMIA Phene_Article / Article\n- 1989. Diabetes Mellitus in the Dog and Cat. Companion Animal Practice — OMIA Phene_Article / Article\n- 1988. Inheritance of diabetes mellitus in Keeshond dogs. American Journal of Veterinary Research — PubMed:PMID3358555 — OMIA Phene_Article / Article\n- 1990. Concurrent Diabetes Mellitus and Hyperadrenocorticism in the Dog - Diagnosis and Management of 8 Cases. Journal of Small Animal Practice — OMIA Phene_Article / Article\n- 1993. Insulin Resistance in 3 Dogs with Hypothyroidism and Diabetes mellitus. Journal of the American Veterinary Medical Association — PubMed:PMID8496104 — OMIA Phene_Article / Article\n- 1993. Plasma Cholesterol and Lipoprotein Concentrations in the Dog - The Effects of Age, Breed, Gender and Endocrine Disease. Journal of Small Animal Practice — OMIA Phene_Article / Article\n- 1994. Hepatic Abscesses Associated with Diabetes Mellitus in 2 Dogs. Journal of Veterinary Internal Medicine — PubMed:PMID8064655 — OMIA Phene_Article / Article\n- 1994. Serum fructosamine as a screening test for diabetes mellitus in non-healthy middle-aged to older dogs. Journal of Veterinary Medicine Series A - Zentralblatt Fur Veterinarmedizin Reihe A - Physiology Pathology Clinical Medicine — OMIA Phene_Article / Article\n- 1995. Diagnosis of diabetes mellitus in dogs and cats - Contrasts and comparisons. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Long-term complications of diabetes mellitus .1. Retinopathy, nephropathy, neuropathy. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Ocular manifestations of diabetes mellitus: Diabetic cataracts in dogs. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Pathophysiology of canine diabetes. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- (97 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIM:125850 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125851 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125852 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125853 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:176730 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:520000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- 1960. The interrelationship between diabetes mellitus, obesity and pyometra in the dog. American Journal of Veterinary Research VL — OMIA Phene_Article / Article\n- 1989. Diabetes Mellitus in the Dog and Cat. Companion Animal Practice — OMIA Phene_Article / Article\n- 1988. Inheritance of diabetes mellitus in Keeshond dogs. American Journal of Veterinary Research — PubMed:PMID3358555 — OMIA Phene_Article / Article\n- 1990. Concurrent Diabetes Mellitus and Hyperadrenocorticism in the Dog - Diagnosis and Management of 8 Cases. Journal of Small Animal Practice — OMIA Phene_Article / Article\n- 1993. Insulin Resistance in 3 Dogs with Hypothyroidism and Diabetes mellitus. Journal of the American Veterinary Medical Association — PubMed:PMID8496104 — OMIA Phene_Article / Article\n- 1993. Plasma Cholesterol and Lipoprotein Concentrations in the Dog - The Effects of Age, Breed, Gender and Endocrine Disease. Journal of Small Animal Practice — OMIA Phene_Article / Article\n- 1994. Hepatic Abscesses Associated with Diabetes Mellitus in 2 Dogs. Journal of Veterinary Internal Medicine — PubMed:PMID8064655 — OMIA Phene_Article / Article\n- 1994. Serum fructosamine as a screening test for diabetes mellitus in non-healthy middle-aged to older dogs. Journal of Veterinary Medicine Series A - Zentralblatt Fur Veterinarmedizin Reihe A - Physiology Pathology Clinical Medicine — OMIA Phene_Article / Article\n- 1995. Diagnosis of diabetes mellitus in dogs and cats - Contrasts and comparisons. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Long-term complications of diabetes mellitus .1. Retinopathy, nephropathy, neuropathy. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Ocular manifestations of diabetes mellitus: Diabetic cataracts in dogs. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- 1995. Pathophysiology of canine diabetes. Veterinary Clinics of North America - Small Animal Practice — OMIA Phene_Article / Article\n- (97 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIM:125850 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125851 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125852 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:125853 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:176730 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:520000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Dog (Canis lupus familiaris) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Dog (Canis lupus familiaris) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/3358555/","retrieved":"","ref":"PMID 3358555","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1608,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}