{"topic_id":"companion_species_health_deafness_lhfpl5_related_cat","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_deafness_lhfpl5_related_cat\ncategory: companion-species-health\ntitle: \"Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/cat_deafness_lhfpl5_related_6757.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 180\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_deafness_lhfpl5_related_cat/01_companion_species_health_deafness_lhfpl5_related_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA003031/9685/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Cat (Felis catus)`\n- `Disorder: Deafness, LHFPL5-related`\n- `Clin feat: Perret et al (2025): \"A 30‐month‐old cat was presented with a chronic history of deafness, vestibular signs, intermittent aggressive behavior, and vocalizations. The owners reported that the cat had never shown any normal response to noise or calling. ...&nbsp; Neurological examination identified loud vocalizations while pacing into the room, which were subjectively judged to be related to hearing impairment rather than pain. A bilateral head swaying movement was also observed together with a low head and body posture close to the ground ... . An ophthalmological examination was unremarkable.\"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398299077 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Perret et al (2025): \"Whole‐genome sequencing of the affected cat [with deafness and vestibular signs] and comparison with 106 control genomes identified a private homozygous splice site variant in the&nbsp;<em>LHFPL5</em> gene, XM_003986102.4:c.413‐2A&gt;G [omia.variant:1862]. ... The LHFPL5 protein is essential for hearing and balance, as it anchors the tip link of inner ear hair cells to the me…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2025. LHFPL5 splice site variant in a cat with deafness and vestibular dysfunction. Anim Genet — PubMed:PMID41400044 | DOI:10.1002/age.70062 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:609427 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610265 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-species-health — Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Cat (Felis catus) — Deafness, LHFPL5-related (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/41400044/","retrieved":"","ref":"PMID 41400044","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":646,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}