{"topic_id":"companion_species_health_achondroplasia_2_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_achondroplasia_2_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — Achondroplasia-2 (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_achondroplasia_2_3843.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 552\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_achondroplasia_2_rabbit/01_companion_species_health_achondroplasia_2_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — Achondroplasia-2 (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001997/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — Achondroplasia-2 (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: Achondroplasia-2`\n- `Mode of inheritance: Sawin and Crary (1959) reported many body measurements that suggested a relatively small effect of the mutant gene in heterozygotes.`\n- `Clin feat: Sawin and Crary (1959): \"The homozygous dachs manifests certain of the typical characteristics of chondrodystrophy but there are certain unique differences. Diminished size and shortening of the limbs appear to be consistent but variable in their expression. Hyperplasia of cartilage in the region of the metaphysis and any profound enlargement of the head seem to be absent except as they may be secondary manifestations or are mildly expressed by individual bone measurements. The depression at the nasion appears to have migrated posteriorly and is accompanied by depression and shift of the orbit and optic foramen. Associated with these are highly localized disproportionate differences which are unlike those noted in any other inherited chondrodystrophy thus far described.\" As summarised by Robinson (1958, p. 341), \"The present case differs from . . . [Achondroplasia-1; OMIA 001996-9986] in several respects. The animals are fully viable and appear quite normal at birth but when adult have the characteristic short legs. Externally the achondroplasia can be recognised by a small cartilaginous papilla arising at the base of the ear. This is present at hirth but is not fully detectable until the ear flap opens at approximately the sixth day and the papilla separates from the remainder of the ear. X-ray plates reveal abnormalities of the leg bones which at a later age may result in crippled legs and a peculiar undulating gait. Dislocations of the hip or knee may appear and become more pronounced as maternity is reached, interfering with normal and successful mating. However, it has been possible to produce young from one [homozygous] female by a normal male. Ear carriage is modified so that it tends to project downward and outward instead of upward and backward. SAWIN (1955) notes that the heterozygote . . . possesses a remnant of the papilla in the same relative position at the ear base.\"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: ac-2 (no structured Phene_Gene link)\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1962. Morphology of the external ear of the dachs (chondrodystrophy) rabbit. American Zoologist — OMIA Phene_Article / Article\n- 1958. Morphogenetic studies of the rabbit. XXI. The nature of disproportionate dwarfism induced by the Da gene revealed by the early fetal ossification pattern. American Journal of Anatomy — PubMed:PMID13626838 | DOI:10.1002/aja.1001030104 — OMIA Phene_Article / Article\n- 1952. A second achondroplasia in the rabbit. Journal of Heredity — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 1965. Morphogenetic studies of the rabbit. XXXV. Pleiotropic effects of the Dachs gene and the gradient growth pattern. J Morphol — PubMed:PMID14336226 | DOI:10.1002/jmor.1051170106 — OMIA Phene_Article / Article\n- 1959. Morphogenetic Studies of the Rabbit. XXIII. the Effects of the Dachs Gene Da (Chondrodystrophy) upon Linear and Lateral Growth of the Skeleton as Influenced in Time. Genetics — PubMed:PMID17247845 | DOI:10.1093/genetics/44.4.609 — OMIA Phene_Article / Article\n- 1959. Morphogenetic studies of the rabbit. XXV. The spheno-occipital synchondrosis of the dachs (chondrodystrophy) rabbit. Am J Anat — PubMed:PMID14442107 | DOI:10.1002/aja.1001050206 — OMIA Phene_Article / Article\n- 1962. Morphogenetic studies of the rabbit. XXIX. Accessory ossification centers at the occipitovertebral articulation of the dachs (chondrodystrophy) rabbit. Am J Anat — PubMed:PMID13986942 | DOI:10.1002/aja.1001110302 — OMIA Phene_Article / Article\n- 1963. Morphogenetic studies of the rabbit. XXXIII. Cartilages and muscles of the external ear as affected by the dachs gene (Da). Am J Anat — PubMed:PMID14072363 | DOI:10.1002/aja.1001130303 — OMIA Phene_Article / Article\n- 1964. Development of the external ear in the dachs rabbit. Anat Rec — PubMed:PMID14248315 | DOI:10.1002/ar.1091500413 — OMIA Phene_Article / Article\n- 1955. Recent genetics of the domestic rabbit. Adv Genet — PubMed:PMID13258375 | DOI:10.1016/s0065-2660(08)60096-6 — OMIA Phene_Article / Article\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — Achondroplasia-2 (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — Achondroplasia-2 (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/13626838/","retrieved":"","ref":"PMID 13626838","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1153,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}