{"topic_id":"companion_species_health_achondroplasia_1_rabbit","category":"companion-species-health","context":"---\nlicense: permission_granted\ntopic_id: companion_species_health_achondroplasia_1_rabbit\ncategory: companion-species-health\ntitle: \"Rabbit (Oryctolagus cuniculus) — Achondroplasia-1 (hereditary; OMIA-verified species predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump.\"\nsource_file: pdf-raw/species-health/rabbit_achondroplasia_1_3842.txt\ndate_parsed: 2026-08-24\ntokens_estimated: 169\nverification:\n  method: substring_match\n  claims: 3\n  passed: 3\n  date: 2026-08-24\nrecovered: false\npath: companion-species-health/companion_species_health_achondroplasia_1_rabbit/01_companion_species_health_achondroplasia_1_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Rabbit (Oryctolagus cuniculus) — Achondroplasia-1 (hereditary; OMIA-verified species predisposition)\"\n  url: \"https://omia.org/OMIA001996/9986/\"\n  retrieved: \"2026-08-24\"\n  ref: \"OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (species-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Rabbit (Oryctolagus cuniculus) — Achondroplasia-1 (hereditary; OMIA-verified species predisposition)\n\nSource: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Species: Rabbit (Oryctolagus cuniculus)`\n- `Disorder: Achondroplasia-1`\n- `Clin feat: As first reported by Brown and Pearce (1945), this form of achondroplasia \"is present at birth and is characterized by size reduction, by a disproportion of bodily parts, most marked in the extremities, and by an invariably lethal effect. The animals are still-born or die very shortly after birth. In physical appearance and in the character of the skeletal changes as shown by x-ray photographs, achondroplasia in the rabbit has a remarkable resemblance to the disease in man and in cattle and dogs.\"`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: Initially ac; later (Robinson, 1958) ac-1 (no structured Phene_Gene link)\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1972. Studies of oxidative energy deficiency. I. Achondroplasia in the rabbit. Arch Biochem Biophys — PubMed:PMID4337533 | DOI:10.1016/0003-9861(72)90020-3 — OMIA Phene_Article / Article\n- 1945. Hereditary achondroplasia in the rabbit: III. Genetic aspects; general considerations. J Exp Med — PubMed:PMID19871500 | DOI:10.1084/jem.82.4.281 — OMIA Phene_Article / Article\n- 1945. Hereditary achondroplasia in the rabbit: II. Pathologic aspects. J Exp Med — PubMed:PMID19871499 | DOI:10.1084/jem.82.4.261 — OMIA Phene_Article / Article\n- 1945. Hereditary achondroplasia in the rabbit: I. Physical appearance and general features. J Exp Med — PubMed:PMID19871498 | DOI:10.1084/jem.82.4.241 — OMIA Phene_Article / Article\n- 1963. Morphogenetic studies of the rabbbit. XXXII. Qualitative skeletal variations induced by the ac gene (achondroplasia). Am J Anat — PubMed:PMID14042510 | DOI:10.1002/aja.1001130103 — OMIA Phene_Article / Article\n- 1971. Organ-culture studies of achondroplastic rabbit cartilage: evidence for a metabolic defect in glucose utilization. J Embryol Exp Morphol — PubMed:PMID5556980 — OMIA Phene_Article / Article\n- 1981. In vitro culture of rabbit growth plate chondrocytes. 2. Chondrodystrophic mutants. Growth — PubMed:PMID6458543 — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 1969. Microscopic studies of achondroplastic rabbit cartilage. Teratology — PubMed:PMID5797691 | DOI:10.1002/tera.1420020103 — OMIA Phene_Article / Article\n","sources":["companion-species-health — Rabbit (Oryctolagus cuniculus) — Achondroplasia-1 (hereditary; OMIA-verified species predisposition)"],"source":{"authority":"companion-species-health","title":"Rabbit (Oryctolagus cuniculus) — Achondroplasia-1 (hereditary; OMIA-verified species predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/4337533/","retrieved":"","ref":"PMID 4337533","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":725,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}