{"topic_id":"companion_breed_health_whippet_congenital_sensorineural_deafness_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_whippet_congenital_sensorineural_deafness_dog\ncategory: companion-breed-health\ntitle: \"Whippet — Congenital sensorineural deafness (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/whippet_congenital_sensorineural_deafness_502.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 556\nverification:\n  method: substring_match\n  claims: 7\n  passed: 7\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_whippet_congenital_sensorineural_deafness_dog/01_companion_breed_health_whippet_congenital_sensorineural_deafness_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Whippet — Congenital sensorineural deafness (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000259/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Whippet — Congenital sensorineural deafness (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Whippet (Dog)`\n- `Disorder: Congenital sensorineural deafness`\n- `Mode of inheritance: Multifactorial`\n- `Summary: This entry focuses on congenital sensorineural deafness for which likely causal variants have so far not been identified. Several other forms of deafness in dogs have a Mendelian mode of inheritance and likely causal variants have been identified, some examples include 'a href=https://omia.org/OMIA002550/9615/OMIA:002550-9615/a : Deafness, EPS8L2-related'; 'a href=https://omia.org/OMIA002336/9615/OMIA:002336-9615/a : Deafness, LOXHD1-related'; 'a href=https://omia.org/OMIA002326/9615/OMIA:002326-9615/a : Deafness, KLF7-related'; 'a href=https://omia.org/OMIA002148/9615/OMIA:002148-9615/a : Deafness, bilateral, and vestibular dysfunction'; 'a href=https://omia.org/OMIA002196/9615/OMIA:002196-9615/a : Deafness, unilateral and vestibular dysfunction'. A separate entry provides information for deafness with adult onset: 'a href=https://omia.org/OMIA001727/9615/OMIA:001727-9615/a : Deafness, adult-onset'.`\n- `Defect: yes`\n- `Prevalence: Lewis et al. (2020): A total of 8955 Dalmatian puppies undergoing hearing function screening using brainstem auditory evoked response (BAER) between July 1992 and February 2019. . . . The overall prevalence of CSD was 17.8% (13.4%, unilateral; 4.4%, bilateral). Marsh et al. (2021) reported that overall CSD [congenital sensorineural deafness] prevalence in the ACD [Australian cattle dog] population in the UK was 11.4%, and puppies with a face patch were at reduced risk of the condition.`\n- `Control: Lewis et al. (2020): A decrease in the prevalence and genetic risk of CSD implies breeders have been selecting for hearing dogs. Selective breeding based on estimated breeding values (EBVs) can help further decrease the prevalence of CSD in Dalmatians in the future. Haase et al. (2022): While many questions remain, we believe that results from this study open the door for genetic testing. In combination with currently applied selection criteria for breeding animals, selecting animals with the protective MITF haplotype will assist with reducing the number of deaf Dalmatians.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: CSD (no structured Phene_Gene link)\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1967. Colour dilution and hereditary defects in Collie dogs. American Journal of Ophthalmology — PubMed:PMID4961230 — OMIA Phene_Article / Article\n- 1924. Congenital deafness in a white bull terrier puppy. Journal of Laryngology and Otology — OMIA Phene_Article / Article\n- 1981. Multiple ocular defects associated with partial albinism and deafness in the dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1956. Hereditary deafness in a family of Foxhounds. Journal of the American Veterinary Medical Association — PubMed:PMID13295142 — OMIA Phene_Article / Article\n- 1933. Congenital deafness in dogs. Our Dog — OMIA Phene_Article / Article\n- 1991. Congenital Deafness in Dogs and Cats. Compendium on Continuing Education for the Practicing  Veterinarian — OMIA Phene_Article / Article\n- 1992. Brainstem Auditory-Evoked Potential Assessment of Congenital  Deafness in Dalmatians - Associations with Phenotypic Markers. Journal of Veterinary Internal Medicine — PubMed:PMID1619594 — OMIA Phene_Article / Article\n- 1992. Unilateral and Bilateral Brainstem Auditory-Evoked Response  Abnormalities in 900 Dalmatian Dogs. Journal of Veterinary Internal Medicine — PubMed:PMID1619593 — OMIA Phene_Article / Article\n- 1994. Deafness in Dalmatians and Other Breeds. Veterinary Record — PubMed:PMID8171802 — OMIA Phene_Article / Article\n- 1994. Inherited deafness among nervous Pointer dogs. J Hered — PubMed:PMID8120360 — OMIA Phene_Article / Article\n- 1994. Hereditary Deafness in the Dalmatian - Relationship to Eye  and Coat Color. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1996. Aetiology, prevalence and diagnosis of deafness in dogs and cats [Review]. Br Vet J — PubMed:PMID8634862 | DOI:10.1016/s0007-1935(96)80083-2 — OMIA Phene_Article / Article\n- (45 additional references in OMIA)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Whippet — Congenital sensorineural deafness (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Whippet — Congenital sensorineural deafness (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/4961230/","retrieved":"","ref":"PMID 4961230","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1040,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}