{"topic_id":"companion_breed_health_siberian_sunshine_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_siberian_sunshine_cat\ncategory: companion-breed-health\ntitle: \"Siberian — Sunshine (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/siberian_sunshine_4507.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 104\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_siberian_sunshine_cat/01_companion_breed_health_siberian_sunshine_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Siberian — Sunshine (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002159/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Siberian — Sunshine (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Siberian (Cat)`\n- `Disorder: Sunshine`\n- `Mode of inheritance: Autosomal recessive`\n- `Defect: no`\n- `Prevalence: Beauvois et al. (2021): The variant was also found in three Kurilian bobtail cats and in two ToyBob cats from the 99 Lives dataset but genotyping of 106 cats from 13 breeds failed to identify carriers in cats from other breeds.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 389725642 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Beauvois et al. (2021): \"A homozygous CORIN:c.2383C&gt;T [omia.variant:1313] missense variant was identified in sunshine tabby cats. Segregation of the variant was consistent with recessive inheritance. . . . The CORIN:c.2383C&gt;T variant was predicted to change an arginine to a cysteine at position 795 in the protein: CORIN:p.(Arg795Cys). Finally, hair observation in Siberian cats was consistent…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2021. Siberian cats help in solving part of the mystery surrounding golden cats. Anim Genet — PubMed:PMID33970502 | DOI:10.1111/age.13076 — OMIA Phene_Article / Article\n- 2022. Golden cats: The story goes on. Anim Genet — PubMed:PMID35574714 | DOI:10.1111/age.13215 — OMIA Phene_Article / Article\n- 2022. Golden cats: A never-ending story!. Anim Genet — PubMed:PMID35703390 | DOI:10.1111/age.13228 — OMIA Phene_Article / Article\n- 2024. Ancestry dynamics and trait selection in a designer cat breed. Curr Biol — PubMed:PMID38531359 | DOI:10.1016/j.cub.2024.02.075 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:605236 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Siberian — Sunshine (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Siberian — Sunshine (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/33970502/","retrieved":"","ref":"PMID 33970502","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":643,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}