{"topic_id":"companion_breed_health_shiba_inu_omia3925_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_shiba_inu_omia3925_dog\ncategory: companion-breed-health\ntitle: \"Shiba Inu — Glaucoma, primary open angle (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/shiba_inu_omia3925_3925.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 109\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_shiba_inu_omia3925_dog/01_companion_breed_health_shiba_inu_omia3925_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Shiba Inu — Glaucoma, primary open angle (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002046/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Shiba Inu — Glaucoma, primary open angle (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Shiba Inu (Dog)`\n- `Disorder: `\n- `Summary: see also entries in OMIA relating to forms of this disease for which causal variants have been identified: e.g., OMIA:001870-9615 : Glaucoma, primary open angle, ADAMTS10-related in Canis lupus familiaris; OMIA:001976-9615 : Glaucoma, primary open angle, ADAMTS17-related in Canis lupus familiaris`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk.. PLoS One — PubMed:PMID24040232 | DOI:10.1371/journal.pone.0074372 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma.. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog.. BMC Vet Res — PubMed:PMID30832652 | DOI:10.1186/s12917-019-1812-1 — OMIA Phene_Article / Article\n- 2022. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels.. Am J Vet Res — PubMed:PMID36170212 | DOI:10.2460/ajvr.22.07.0106 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One — PubMed:PMID24040232 | DOI:10.1371/journal.pone.0074372 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res — PubMed:PMID30832652 | DOI:10.1186/s12917-019-1812-1 — OMIA Phene_Article / Article\n- 2022. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res — PubMed:PMID36170212 | DOI:10.2460/ajvr.22.07.0106 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One — PubMed:PMID24040232 | DOI:10.1371/journal.pone.0074372 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res — PubMed:PMID30832652 | DOI:10.1186/s12917-019-1812-1 — OMIA Phene_Article / Article\n- 2022. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res — PubMed:PMID36170212 | DOI:10.2460/ajvr.22.07.0106 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One — PubMed:PMID24040232 | DOI:10.1371/journal.pone.0074372 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res — PubMed:PMID30832652 | DOI:10.1186/s12917-019-1812-1 — OMIA Phene_Article / Article\n- 2022. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res — PubMed:PMID36170212 | DOI:10.2460/ajvr.22.07.0106 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk. PLoS One — PubMed:PMID24040232 | DOI:10.1371/journal.pone.0074372 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res — PubMed:PMID30832652 | DOI:10.1186/s12917-019-1812-1 — OMIA Phene_Article / Article\n- 2022. A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. Am J Vet Res — PubMed:PMID36170212 | DOI:10.2460/ajvr.22.07.0106 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Shiba Inu — Glaucoma, primary open angle (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Shiba Inu — Glaucoma, primary open angle (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/24040232/","retrieved":"","ref":"PMID 24040232","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1346,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}