{"topic_id":"companion_breed_health_shetland_sheepdog_omia4412_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_shetland_sheepdog_omia4412_dog\ncategory: companion-breed-health\ntitle: \"Shetland Sheepdog — Maxillary canine-tooth mesioversion (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/shetland_sheepdog_omia4412_4412.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 130\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_shetland_sheepdog_omia4412_dog/01_companion_breed_health_shetland_sheepdog_omia4412_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Shetland Sheepdog — Maxillary canine-tooth mesioversion (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002291/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Shetland Sheepdog — Maxillary canine-tooth mesioversion (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Shetland Sheepdog (Dog)`\n- `Disorder: `\n- `Clin feat: Abrams et al. 92020): maxillary canine-tooth mesioversion (MCM) describes an upper canine tooth that is displaced forward toward the nose, also known as a lance canine . . . . One or both maxillary canines may be affected. MCM can cause traumatic occlusion, ulceration of the upper lip, and/or periodontal disease and may require extraction or orthodontic repositioning.`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2020. Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs.. Proc Natl Acad Sci U S A — PubMed:PMID32958658 | DOI:10.1073/pnas.2009500117 — OMIA Phene_Article / Article\n- 2008. Correction of maxillary canine tooth mesioversion in dogs.. J Vet Dent — PubMed:PMID19025142 | DOI:10.1177/089875640802500312 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2020. Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A — PubMed:PMID32958658 | DOI:10.1073/pnas.2009500117 — OMIA Phene_Article / Article\n- 2008. Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent — PubMed:PMID19025142 | DOI:10.1177/089875640802500312 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2020. Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A — PubMed:PMID32958658 | DOI:10.1073/pnas.2009500117 — OMIA Phene_Article / Article\n- 2008. Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent — PubMed:PMID19025142 | DOI:10.1177/089875640802500312 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2020. Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A — PubMed:PMID32958658 | DOI:10.1073/pnas.2009500117 — OMIA Phene_Article / Article\n- 2008. Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent — PubMed:PMID19025142 | DOI:10.1177/089875640802500312 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2020. Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A — PubMed:PMID32958658 | DOI:10.1073/pnas.2009500117 — OMIA Phene_Article / Article\n- 2008. Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent — PubMed:PMID19025142 | DOI:10.1177/089875640802500312 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Shetland Sheepdog — Maxillary canine-tooth mesioversion (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Shetland Sheepdog — Maxillary canine-tooth mesioversion (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/32958658/","retrieved":"","ref":"PMID 32958658","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":982,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}