{"topic_id":"companion_breed_health_shetland_pony_horse_omia3790_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_shetland_pony_horse_omia3790_horse\ncategory: companion-breed-health\ntitle: \"Shetland Pony (Horse) — Coat colour, dun (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/shetland_pony_horse_omia3790_3790.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 183\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_shetland_pony_horse_omia3790_horse/01_companion_breed_health_shetland_pony_horse_omia3790_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Shetland Pony (Horse) — Coat colour, dun (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001972/9796/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Shetland Pony (Horse) — Coat colour, dun (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Shetland Pony (Horse)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal dominant`\n- `Summary: Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. (Imsland et al., 2016). Primitive markings usually appear as a dorsal stripe and bars on the legs. Primitive markings usually appear as a dorsal stripe and bars on the legs. These primitive markings were discussed at some length by Darwin (1859) (chap 5, pp. 163-167).br[IT thanks Haley Rutstein, working under the guidance of Professor Ernie Bailey, for contributions to this entry in April 2024]`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 388946510 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Following mapping, the candidate region was DNA sequenced leading to the discovery of a pair of insertions associated with the D and d1 alleles. The D allele appears as an 8 bp insertion followed downstream by a 1609 bp insertion. The d1 allele, described as having no dilution but showing primitive markings, appears as an 8 bp insertion followed downstream by a 1610 bp insertion. The d2 allele is …\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1859. On the Origin of Species by Means of Natural Selection. John Murray, London — OMIA Phene_Article / Article\n- 1978. Inheritance of yellow dun and blue dun in the Icelandic toelter horse. J Hered — PubMed:PMID731005 | DOI:10.1093/oxfordjournals.jhered.a108913 — OMIA Phene_Article / Article\n- 2016. Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses. Nat Genet — PubMed:PMID26691985 | DOI:10.1038/ng.3475 — OMIA Phene_Article / Article\n- 2019. TBX3 and ASIP genotypes reveal discrepancies in officially recorded coat colors of Hucul horses. Animal — PubMed:PMID30614426 | DOI:10.1017/S1751731118003506 — OMIA Phene_Article / Article\n- 2021. Genetic background of the Polish primitive horse (Konik) coat color variation-new insight into dun dilution phenotypic effect. J Hered — PubMed:PMID34432873 | DOI:10.1093/jhered/esab034 — OMIA Phene_Article / Article\n- 2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article\n- 2023. Evaluation of genetic markers in the analysis of the colors and marks occurrence in the Vyatka breed horses. Vestnik of the Russian Agricultural Science — DOI:10.31857/2500-2082/2023/3/89-94 — OMIA Phene_Article / Article\n- 2017. Variation in TBX3 gene region in dun coat color Polish Konik horses. Journal of Equine Veterinary Science — DOI:10.1016/j.jevs.2016.10.003 — OMIA Phene_Article / Article\n- 2024. Expression and analysis of TBX3 gene in the skin from three locations on dun Mongolian Bider horse. Genes (Basel) — PubMed:PMID39766856 | DOI:10.3390/genes15121589 — OMIA Phene_Article / Article\n- 2026. Differential expression and analysis of TBX3 gene in skin tissues of dun mongolian horses with and without bider markings. Animals (Basel) — PubMed:PMID41594486 | DOI:10.3390/ani16020297 — OMIA Phene_Article / Article\n- 2026. Genetic background and phenotypic features of the endangered Miyako horse. J Equine Sci — PubMed:PMID41859759 | DOI:10.1294/jes.37.27 — OMIA Phene_Article / Article\n- 2026. Unraveling the molecular mechanism of Bider marking formation in dun Mongolian horses through transcriptome sequencing. Animals (Basel) — PubMed:PMID42071913 | DOI:10.3390/ani16081145 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:601621 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Shetland Pony (Horse) — Coat colour, dun (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Shetland Pony (Horse) — Coat colour, dun (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/731005/","retrieved":"","ref":"PMID 731005","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1051,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}