{"topic_id":"companion_breed_health_scottish_fold_scottish_fold_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_scottish_fold_scottish_fold_cat\ncategory: companion-breed-health\ntitle: \"Scottish Fold — Scottish Fold. (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/scottish_fold_scottish_fold_2549.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_scottish_fold_scottish_fold_cat/01_companion_breed_health_scottish_fold_scottish_fold_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Scottish Fold — Scottish Fold. (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001315/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Scottish Fold — Scottish Fold. (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Scottish Fold (Cat)`\n- `Disorder: Scottish Fold.`\n- `Mode of inheritance: Autosomal incomplete dominant`\n- `Summary: See OMIA entry for Ears, folded (a href=../../../../../../OMIA000319/9685/OMIA:000319-9685/a)`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1999. Osteochondrodysplasia in Scottish Fold cats. Australian Veterinary Journal — PubMed:PMID10078353 | DOI:10.1111/j.1751-0813.1999.tb11672.x — OMIA Phene_Article / Article\n- 2004. Palliative irradiation of Scottish Fold osteochondrodysplasia.. Vet Radiol Ultrasound — PubMed:PMID15605854 | DOI:10.1111/j.1740-8261.2004.04101.x — OMIA Phene_Article / Article\n- 2008. Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats.. J Small Anim Pract — PubMed:PMID18339089 | DOI:10.1111/j.1748-5827.2008.00561.x — OMIA Phene_Article / Article\n- 2007. Osteochondrodysplasia in three Scottish Fold cats.. J Vet Sci — PubMed:PMID17679781 | DOI:10.4142/jvs.2007.8.3.307 — OMIA Phene_Article / Article\n- 2002. Osteochondrodysplasia in poodle cats (Rex Fold). Kleintierpraxis — OMIA Phene_Article / Article\n- 2000. Osteochondrodystrophy in the Scottish fold cat. Tierarztliche Praxis Ausgabe Kleintiere Heimtiere — OMIA Phene_Article / Article\n- 2016. A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.. Osteoarthritis Cartilage — PubMed:PMID27063440 | DOI:10.1016/j.joca.2016.03.019 — OMIA Phene_Article / Article\n- 2019. Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid.. J Am Anim Hosp Assoc — PubMed:PMID30870611 | DOI:10.5326/JAAHA-MS-6797 — OMIA Phene_Article / Article\n- 2021. Radiographical survey of osteochondrodysplasia in Scottish Fold cats caused by the TRPV4 gene variant.. Hum Genet — PubMed:PMID34406467 | DOI:10.1007/s00439-021-02337-5 — OMIA Phene_Article / Article\n- 2020. Osteochondrodysplasia in Scottish Fold cross-breed cats.. J Vet Med Sci — PubMed:PMID33162427 | DOI:10.1292/jvms.20-0299 — OMIA Phene_Article / Article\n- 2020. Combined surgical, radiation, and medical therapies for osteochondrodysplasia in a Scottish Fold cat.. J Am Anim Hosp Assoc — PubMed:PMID32182117 | DOI:10.5326/JAAHA-MS-6980 — OMIA Phene_Article / Article\n- 2015. Efficacy and complications of palliative irradiation in three Scottish Fold cats with osteochondrodysplasia.. J Vet Intern Med — PubMed:PMID26365740 | DOI:10.1111/jvim.13614 — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:600972 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256050 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:226900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1999. Osteochondrodysplasia in Scottish Fold cats. Australian Veterinary Journal — PubMed:PMID10078353 | DOI:10.1111/j.1751-0813.1999.tb11672.x — OMIA Phene_Article / Article\n- 2004. Palliative irradiation of Scottish Fold osteochondrodysplasia. Vet Radiol Ultrasound — PubMed:PMID15605854 | DOI:10.1111/j.1740-8261.2004.04101.x — OMIA Phene_Article / Article\n- 2008. Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats. J Small Anim Pract — PubMed:PMID18339089 | DOI:10.1111/j.1748-5827.2008.00561.x — OMIA Phene_Article / Article\n- 2007. Osteochondrodysplasia in three Scottish Fold cats. J Vet Sci — PubMed:PMID17679781 | DOI:10.4142/jvs.2007.8.3.307 — OMIA Phene_Article / Article\n- 2002. Osteochondrodysplasia in poodle cats (Rex Fold). Kleintierpraxis — OMIA Phene_Article / Article\n- 2000. Osteochondrodystrophy in the Scottish fold cat. Tierarztliche Praxis Ausgabe Kleintiere Heimtiere — OMIA Phene_Article / Article\n- 2016. A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats. Osteoarthritis Cartilage — PubMed:PMID27063440 | DOI:10.1016/j.joca.2016.03.019 — OMIA Phene_Article / Article\n- 2019. Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid. J Am Anim Hosp Assoc — PubMed:PMID30870611 | DOI:10.5326/JAAHA-MS-6797 — OMIA Phene_Article / Article\n- 2021. Radiographical survey of osteochondrodysplasia in Scottish Fold cats caused by the TRPV4 gene variant. Hum Genet — PubMed:PMID34406467 | DOI:10.1007/s00439-021-02337-5 — OMIA Phene_Article / Article\n- 2020. Osteochondrodysplasia in Scottish Fold cross-breed cats. J Vet Med Sci — PubMed:PMID33162427 | DOI:10.1292/jvms.20-0299 — OMIA Phene_Article / Article\n- 2020. Combined surgical, radiation, and medical therapies for osteochondrodysplasia in a Scottish Fold cat. J Am Anim Hosp Assoc — PubMed:PMID32182117 | DOI:10.5326/JAAHA-MS-6980 — OMIA Phene_Article / Article\n- 2015. Efficacy and complications of palliative irradiation in three Scottish Fold cats with osteochondrodysplasia. J Vet Intern Med — PubMed:PMID26365740 | DOI:10.1111/jvim.13614 — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:600972 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256050 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:226900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1999. Osteochondrodysplasia in Scottish Fold cats. Australian Veterinary Journal — PubMed:PMID10078353 | DOI:10.1111/j.1751-0813.1999.tb11672.x — OMIA Phene_Article / Article\n- 2004. Palliative irradiation of Scottish Fold osteochondrodysplasia. Vet Radiol Ultrasound — PubMed:PMID15605854 | DOI:10.1111/j.1740-8261.2004.04101.x — OMIA Phene_Article / Article\n- 2008. Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats. J Small Anim Pract — PubMed:PMID18339089 | DOI:10.1111/j.1748-5827.2008.00561.x — OMIA Phene_Article / Article\n- 2007. Osteochondrodysplasia in three Scottish Fold cats. J Vet Sci — PubMed:PMID17679781 | DOI:10.4142/jvs.2007.8.3.307 — OMIA Phene_Article / Article\n- 2002. Osteochondrodysplasia in poodle cats (Rex Fold). Kleintierpraxis — OMIA Phene_Article / Article\n- 2000. Osteochondrodystrophy in the Scottish fold cat. Tierarztliche Praxis Ausgabe Kleintiere Heimtiere — OMIA Phene_Article / Article\n- 2016. A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats. Osteoarthritis Cartilage — PubMed:PMID27063440 | DOI:10.1016/j.joca.2016.03.019 — OMIA Phene_Article / Article\n- 2019. Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid. J Am Anim Hosp Assoc — PubMed:PMID30870611 | DOI:10.5326/JAAHA-MS-6797 — OMIA Phene_Article / Article\n- 2021. Radiographical survey of osteochondrodysplasia in Scottish Fold cats caused by the TRPV4 gene variant. Hum Genet — PubMed:PMID34406467 | DOI:10.1007/s00439-021-02337-5 — OMIA Phene_Article / Article\n- 2020. Osteochondrodysplasia in Scottish Fold cross-breed cats. J Vet Med Sci — PubMed:PMID33162427 | DOI:10.1292/jvms.20-0299 — OMIA Phene_Article / Article\n- 2020. Combined surgical, radiation, and medical therapies for osteochondrodysplasia in a Scottish Fold cat. J Am Anim Hosp Assoc — PubMed:PMID32182117 | DOI:10.5326/JAAHA-MS-6980 — OMIA Phene_Article / Article\n- 2015. Efficacy and complications of palliative irradiation in three Scottish Fold cats with osteochondrodysplasia. J Vet Intern Med — PubMed:PMID26365740 | DOI:10.1111/jvim.13614 — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:600972 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256050 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:226900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1999. Osteochondrodysplasia in Scottish Fold cats. Australian Veterinary Journal — PubMed:PMID10078353 | DOI:10.1111/j.1751-0813.1999.tb11672.x — OMIA Phene_Article / Article\n- 2004. Palliative irradiation of Scottish Fold osteochondrodysplasia. Vet Radiol Ultrasound — PubMed:PMID15605854 | DOI:10.1111/j.1740-8261.2004.04101.x — OMIA Phene_Article / Article\n- 2008. Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats. J Small Anim Pract — PubMed:PMID18339089 | DOI:10.1111/j.1748-5827.2008.00561.x — OMIA Phene_Article / Article\n- 2007. Osteochondrodysplasia in three Scottish Fold cats. J Vet Sci — PubMed:PMID17679781 | DOI:10.4142/jvs.2007.8.3.307 — OMIA Phene_Article / Article\n- 2002. Osteochondrodysplasia in poodle cats (Rex Fold). Kleintierpraxis — OMIA Phene_Article / Article\n- 2000. Osteochondrodystrophy in the Scottish fold cat. Tierarztliche Praxis Ausgabe Kleintiere Heimtiere — OMIA Phene_Article / Article\n- 2016. A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats. Osteoarthritis Cartilage — PubMed:PMID27063440 | DOI:10.1016/j.joca.2016.03.019 — OMIA Phene_Article / Article\n- 2019. Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid. J Am Anim Hosp Assoc — PubMed:PMID30870611 | DOI:10.5326/JAAHA-MS-6797 — OMIA Phene_Article / Article\n- 2021. Radiographical survey of osteochondrodysplasia in Scottish Fold cats caused by the TRPV4 gene variant. Hum Genet — PubMed:PMID34406467 | DOI:10.1007/s00439-021-02337-5 — OMIA Phene_Article / Article\n- 2020. Osteochondrodysplasia in Scottish Fold cross-breed cats. J Vet Med Sci — PubMed:PMID33162427 | DOI:10.1292/jvms.20-0299 — OMIA Phene_Article / Article\n- 2020. Combined surgical, radiation, and medical therapies for osteochondrodysplasia in a Scottish Fold cat. J Am Anim Hosp Assoc — PubMed:PMID32182117 | DOI:10.5326/JAAHA-MS-6980 — OMIA Phene_Article / Article\n- 2015. Efficacy and complications of palliative irradiation in three Scottish Fold cats with osteochondrodysplasia. J Vet Intern Med — PubMed:PMID26365740 | DOI:10.1111/jvim.13614 — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:600972 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256050 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:226900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1999. Osteochondrodysplasia in Scottish Fold cats. Australian Veterinary Journal — PubMed:PMID10078353 | DOI:10.1111/j.1751-0813.1999.tb11672.x — OMIA Phene_Article / Article\n- 2004. Palliative irradiation of Scottish Fold osteochondrodysplasia. Vet Radiol Ultrasound — PubMed:PMID15605854 | DOI:10.1111/j.1740-8261.2004.04101.x — OMIA Phene_Article / Article\n- 2008. Incomplete dominant osteochondrodysplasia in heterozygous Scottish Fold cats. J Small Anim Pract — PubMed:PMID18339089 | DOI:10.1111/j.1748-5827.2008.00561.x — OMIA Phene_Article / Article\n- 2007. Osteochondrodysplasia in three Scottish Fold cats. J Vet Sci — PubMed:PMID17679781 | DOI:10.4142/jvs.2007.8.3.307 — OMIA Phene_Article / Article\n- 2002. Osteochondrodysplasia in poodle cats (Rex Fold). Kleintierpraxis — OMIA Phene_Article / Article\n- 2000. Osteochondrodystrophy in the Scottish fold cat. Tierarztliche Praxis Ausgabe Kleintiere Heimtiere — OMIA Phene_Article / Article\n- 2016. A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats. Osteoarthritis Cartilage — PubMed:PMID27063440 | DOI:10.1016/j.joca.2016.03.019 — OMIA Phene_Article / Article\n- 2019. Osteochondrodysplasia in a Scottish Fold cat treated with radiation therapy and samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonic acid. J Am Anim Hosp Assoc — PubMed:PMID30870611 | DOI:10.5326/JAAHA-MS-6797 — OMIA Phene_Article / Article\n- 2021. Radiographical survey of osteochondrodysplasia in Scottish Fold cats caused by the TRPV4 gene variant. Hum Genet — PubMed:PMID34406467 | DOI:10.1007/s00439-021-02337-5 — OMIA Phene_Article / Article\n- 2020. Osteochondrodysplasia in Scottish Fold cross-breed cats. J Vet Med Sci — PubMed:PMID33162427 | DOI:10.1292/jvms.20-0299 — OMIA Phene_Article / Article\n- 2020. Combined surgical, radiation, and medical therapies for osteochondrodysplasia in a Scottish Fold cat. J Am Anim Hosp Assoc — PubMed:PMID32182117 | DOI:10.5326/JAAHA-MS-6980 — OMIA Phene_Article / Article\n- 2015. Efficacy and complications of palliative irradiation in three Scottish Fold cats with osteochondrodysplasia. J Vet Intern Med — PubMed:PMID26365740 | DOI:10.1111/jvim.13614 — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:600972 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256050 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:226900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:222600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Scottish Fold — Scottish Fold. (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Scottish Fold — Scottish Fold. (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/10078353/","retrieved":"","ref":"PMID 10078353","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2743,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}