{"topic_id":"companion_breed_health_saarloos_wolfhond_omia569_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_saarloos_wolfhond_omia569_dog\ncategory: companion-breed-health\ntitle: \"Saarloos Wolfhond — Pituitary hormone deficiency, generic (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/saarloos_wolfhond_omia569_569.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 120\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_saarloos_wolfhond_omia569_dog/01_companion_breed_health_saarloos_wolfhond_omia569_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Saarloos Wolfhond — Pituitary hormone deficiency, generic (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000307/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Saarloos Wolfhond — Pituitary hormone deficiency, generic (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Saarloos Wolfhond (Dog)`\n- `Disorder: `\n- `Summary: see also OMIA entries that refer to gene-relaed forms of pituitary dwarfism, e.g.nbsp; a href=https://omia.org/OMIA002315/9615/OMIA:002315-9615 /a: Dwarfism, pituitary, POU1F1-related in Canis lupus familiaris and a href=https://omia.org/OMIA002314/9615/OMIA:002314-9615/a : Dwarfism, pituitary, LHX3-related in Canis lupus familiaris`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1976. Pituitary dwarfism in German Shepherd dogs : additional evidence of simple, autosomal recessive inheritance. Nordisk Veterinaermedicin — PubMed:PMID980693 — OMIA Phene_Article / Article\n- 1974. Pituitary dwarfism in German Shepherd dogs : genetic investigations. Nordisk Veterinaermedicin — PubMed:PMID4449724 — OMIA Phene_Article / Article\n- 1975. Pituitary dwarfism in German Shepherd dogs: studies on somatomedin activity. Nordisk Veterinaermedicin — PubMed:PMID1178442 — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs. Journal of Small Animal Practice — PubMed:PMID723236 — OMIA Phene_Article / Article\n- 1976. Somatomedin levels in dogs with pituitary dwarfism. Hereditas — OMIA Phene_Article / Article\n- 1975. Hereditary pituitary dwarfism in German Shepherd dogs. Hunden. Medlemsblad Dansk Kennel Klub — OMIA Phene_Article / Article\n- 1978. Origin and distribution of pituitary dwarfism in the dog and a basis for detecting carriers of various genetic diseases using biochemical methods. Kleintierpraxis — OMIA Phene_Article / Article\n- 1981. Diagnosis and treatment of dwarfism in a German Shepherd dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs: a genetic analysis of some Australian data. Journal of Small Animal Practice — PubMed:PMID642476 — OMIA Phene_Article / Article\n- 1990. Delayed growth in 2 German Shepherd dog littermates with normal serum concentrations of growth hormone, thyroxine, and cortisol.. J Am Vet Med Assoc — PubMed:PMID2295557 — OMIA Phene_Article / Article\n- 1991. Congenital hypothyroid dwarfism in a family of Giant Schnauzers.. J Vet Intern Med — PubMed:PMID2061865 | DOI:10.1111/j.1939-1676.1991.tb00932.x — OMIA Phene_Article / Article\n- 1993. Disturbed release of growth hormone in mature dogs - A comparison with congenital growth hormone deficiency.. Vet Rec — PubMed:PMID8116157 | DOI:10.1136/vr.133.22.542 — OMIA Phene_Article / Article\n- (23 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:221750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1976. Pituitary dwarfism in German Shepherd dogs : additional evidence of simple, autosomal recessive inheritance. Nordisk Veterinaermedicin — PubMed:PMID980693 — OMIA Phene_Article / Article\n- 1974. Pituitary dwarfism in German Shepherd dogs : genetic investigations. Nordisk Veterinaermedicin — PubMed:PMID4449724 — OMIA Phene_Article / Article\n- 1975. Pituitary dwarfism in German Shepherd dogs: studies on somatomedin activity. Nordisk Veterinaermedicin — PubMed:PMID1178442 — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs. Journal of Small Animal Practice — PubMed:PMID723236 — OMIA Phene_Article / Article\n- 1976. Somatomedin levels in dogs with pituitary dwarfism. Hereditas — OMIA Phene_Article / Article\n- 1975. Hereditary pituitary dwarfism in German Shepherd dogs. Hunden. Medlemsblad Dansk Kennel Klub — OMIA Phene_Article / Article\n- 1978. Origin and distribution of pituitary dwarfism in the dog and a basis for detecting carriers of various genetic diseases using biochemical methods. Kleintierpraxis — OMIA Phene_Article / Article\n- 1981. Diagnosis and treatment of dwarfism in a German Shepherd dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs: a genetic analysis of some Australian data. Journal of Small Animal Practice — PubMed:PMID642476 — OMIA Phene_Article / Article\n- 1990. Delayed growth in 2 German Shepherd dog littermates with normal serum concentrations of growth hormone, thyroxine, and cortisol. J Am Vet Med Assoc — PubMed:PMID2295557 — OMIA Phene_Article / Article\n- 1991. Congenital hypothyroid dwarfism in a family of Giant Schnauzers. J Vet Intern Med — PubMed:PMID2061865 | DOI:10.1111/j.1939-1676.1991.tb00932.x — OMIA Phene_Article / Article\n- 1993. Disturbed release of growth hormone in mature dogs - A comparison with congenital growth hormone deficiency. Vet Rec — PubMed:PMID8116157 | DOI:10.1136/vr.133.22.542 — OMIA Phene_Article / Article\n- (23 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:221750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Pituitary dwarfism in German Shepherd dogs : additional evidence of simple, autosomal recessive inheritance. Nordisk Veterinaermedicin — PubMed:PMID980693 — OMIA Phene_Article / Article\n- 1974. Pituitary dwarfism in German Shepherd dogs : genetic investigations. Nordisk Veterinaermedicin — PubMed:PMID4449724 — OMIA Phene_Article / Article\n- 1975. Pituitary dwarfism in German Shepherd dogs: studies on somatomedin activity. Nordisk Veterinaermedicin — PubMed:PMID1178442 — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs. Journal of Small Animal Practice — PubMed:PMID723236 — OMIA Phene_Article / Article\n- 1976. Somatomedin levels in dogs with pituitary dwarfism. Hereditas — OMIA Phene_Article / Article\n- 1975. Hereditary pituitary dwarfism in German Shepherd dogs. Hunden. Medlemsblad Dansk Kennel Klub — OMIA Phene_Article / Article\n- 1978. Origin and distribution of pituitary dwarfism in the dog and a basis for detecting carriers of various genetic diseases using biochemical methods. Kleintierpraxis — OMIA Phene_Article / Article\n- 1981. Diagnosis and treatment of dwarfism in a German Shepherd dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs: a genetic analysis of some Australian data. Journal of Small Animal Practice — PubMed:PMID642476 — OMIA Phene_Article / Article\n- 1990. Delayed growth in 2 German Shepherd dog littermates with normal serum concentrations of growth hormone, thyroxine, and cortisol. J Am Vet Med Assoc — PubMed:PMID2295557 — OMIA Phene_Article / Article\n- 1991. Congenital hypothyroid dwarfism in a family of Giant Schnauzers. J Vet Intern Med — PubMed:PMID2061865 | DOI:10.1111/j.1939-1676.1991.tb00932.x — OMIA Phene_Article / Article\n- 1993. Disturbed release of growth hormone in mature dogs - A comparison with congenital growth hormone deficiency. Vet Rec — PubMed:PMID8116157 | DOI:10.1136/vr.133.22.542 — OMIA Phene_Article / Article\n- (23 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:221750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Pituitary dwarfism in German Shepherd dogs : additional evidence of simple, autosomal recessive inheritance. Nordisk Veterinaermedicin — PubMed:PMID980693 — OMIA Phene_Article / Article\n- 1974. Pituitary dwarfism in German Shepherd dogs : genetic investigations. Nordisk Veterinaermedicin — PubMed:PMID4449724 — OMIA Phene_Article / Article\n- 1975. Pituitary dwarfism in German Shepherd dogs: studies on somatomedin activity. Nordisk Veterinaermedicin — PubMed:PMID1178442 — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs. Journal of Small Animal Practice — PubMed:PMID723236 — OMIA Phene_Article / Article\n- 1976. Somatomedin levels in dogs with pituitary dwarfism. Hereditas — OMIA Phene_Article / Article\n- 1975. Hereditary pituitary dwarfism in German Shepherd dogs. Hunden. Medlemsblad Dansk Kennel Klub — OMIA Phene_Article / Article\n- 1978. Origin and distribution of pituitary dwarfism in the dog and a basis for detecting carriers of various genetic diseases using biochemical methods. Kleintierpraxis — OMIA Phene_Article / Article\n- 1981. Diagnosis and treatment of dwarfism in a German Shepherd dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs: a genetic analysis of some Australian data. Journal of Small Animal Practice — PubMed:PMID642476 — OMIA Phene_Article / Article\n- 1990. Delayed growth in 2 German Shepherd dog littermates with normal serum concentrations of growth hormone, thyroxine, and cortisol. J Am Vet Med Assoc — PubMed:PMID2295557 — OMIA Phene_Article / Article\n- 1991. Congenital hypothyroid dwarfism in a family of Giant Schnauzers. J Vet Intern Med — PubMed:PMID2061865 | DOI:10.1111/j.1939-1676.1991.tb00932.x — OMIA Phene_Article / Article\n- 1993. Disturbed release of growth hormone in mature dogs - A comparison with congenital growth hormone deficiency. Vet Rec — PubMed:PMID8116157 | DOI:10.1136/vr.133.22.542 — OMIA Phene_Article / Article\n- (23 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:221750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Pituitary dwarfism in German Shepherd dogs : additional evidence of simple, autosomal recessive inheritance. Nordisk Veterinaermedicin — PubMed:PMID980693 — OMIA Phene_Article / Article\n- 1974. Pituitary dwarfism in German Shepherd dogs : genetic investigations. Nordisk Veterinaermedicin — PubMed:PMID4449724 — OMIA Phene_Article / Article\n- 1975. Pituitary dwarfism in German Shepherd dogs: studies on somatomedin activity. Nordisk Veterinaermedicin — PubMed:PMID1178442 — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs. Journal of Small Animal Practice — PubMed:PMID723236 — OMIA Phene_Article / Article\n- 1976. Somatomedin levels in dogs with pituitary dwarfism. Hereditas — OMIA Phene_Article / Article\n- 1975. Hereditary pituitary dwarfism in German Shepherd dogs. Hunden. Medlemsblad Dansk Kennel Klub — OMIA Phene_Article / Article\n- 1978. Origin and distribution of pituitary dwarfism in the dog and a basis for detecting carriers of various genetic diseases using biochemical methods. Kleintierpraxis — OMIA Phene_Article / Article\n- 1981. Diagnosis and treatment of dwarfism in a German Shepherd dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1978. Pituitary dwarfism in German Shepherd dogs: a genetic analysis of some Australian data. Journal of Small Animal Practice — PubMed:PMID642476 — OMIA Phene_Article / Article\n- 1990. Delayed growth in 2 German Shepherd dog littermates with normal serum concentrations of growth hormone, thyroxine, and cortisol. J Am Vet Med Assoc — PubMed:PMID2295557 — OMIA Phene_Article / Article\n- 1991. Congenital hypothyroid dwarfism in a family of Giant Schnauzers. J Vet Intern Med — PubMed:PMID2061865 | DOI:10.1111/j.1939-1676.1991.tb00932.x — OMIA Phene_Article / Article\n- 1993. Disturbed release of growth hormone in mature dogs - A comparison with congenital growth hormone deficiency. Vet Rec — PubMed:PMID8116157 | DOI:10.1136/vr.133.22.542 — OMIA Phene_Article / Article\n- (23 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:221750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Saarloos Wolfhond — Pituitary hormone deficiency, generic (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Saarloos Wolfhond — Pituitary hormone deficiency, generic (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/980693/","retrieved":"","ref":"PMID 980693","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2696,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}