{"topic_id":"companion_breed_health_quarter_horse_horse_palomino_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_quarter_horse_horse_palomino_horse\ncategory: companion-breed-health\ntitle: \"Quarter Horse (Horse) — Palomino (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/quarter_horse_horse_palomino_2663.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 106\nverification:\n method: substring_match\n claims: 5\n passed: 5\n date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_quarter_horse_horse_palomino_horse/01_companion_breed_health_quarter_horse_horse_palomino_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n title: \"Quarter Horse (Horse) — Palomino (hereditary; OMIA-verified breed predisposition)\"\n url: \"https://omia.org/OMIA001344/9796/\"\n retrieved: \"2026-08-23\"\n ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n needs_review: false\n\nverification_derived:\n method: derived_from_dataset\n source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Quarter Horse (Horse) — Palomino (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Quarter Horse (Horse)`\n- `Disorder: Palomino`\n- `Mode of inheritance: Autosomal`\n- `Summary: In 2003, Mariat et al. showed that this classic coat-colour locus encodes membrane-associated transporter protein (MATP), now renamed emSLC45A2/em, and that the first reported dilution allele in horses is due to a missense mutation [FN 16 Oct 2003].`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- Gene: MATP (Entrez Gene ID 5474234) — OMIA Phene_Gene / GeneSynonym\n- OMIA molecular-genetics note: Building on the strong evidence from mapping (see Mapping section above), Mariat et al. (2003) identified a missense G457A transition (omia.variant:153) in the equine MATP gene (now called SLC45A2), giving rise to a D153N amino acid substitution in cream horses. Sevane et al. (2019) reported a \"missense variation in exon 4 [SLC45A2:c.985G>A; SLC45A2:p.(Ala329Thr), omia.variant…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- 1951. New evidence on the genetics of the Palomino horse. J Hered — PubMed:PMID14832452 — OMIA Phene_Article / Article\n- 2001. The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21. Animal Genetics — PubMed:PMID11736803 — OMIA Phene_Article / Article\n- 2003. A mutation in the MATP gene causes the cream coat colour in the horse. Genetics Selection Evolution — PubMed:PMID12605854 | DOI:10.1051/gse:2002039 — OMIA Phene_Article / Article\n- 2008. Technical note: a novel method for routine genotyping of horse coat color gene polymorphisms. J Anim Sci — PubMed:PMID18310485 | DOI:10.2527/jas.2007-0498 — OMIA Phene_Article / Article\n- 2009. Development of a method for simultaneously genotyping multiple horse coat colour loci and genetic investigation of basic colour variation in Thoroughbred and Misaki horses in Japan. J Anim Breed Genet — PubMed:PMID19912416 | DOI:10.1111/j.1439-0388.2009.00841.x — OMIA Phene_Article / Article\n- 2009. Genetics. It's a bull's market. Science — PubMed:PMID19390037 | DOI:10.1126/science.1173880 — OMIA Phene_Article / Article\n- 2009. Molecular tests for coat colours in horses. J Anim Breed Genet — PubMed:PMID19912415 | DOI:10.1111/j.1439-0388.2009.00832.x — OMIA Phene_Article / Article\n- 2010. Pleiotropic effects of pigmentation genes in horses. Anim Genet — PubMed:PMID21070283 | DOI:10.1111/j.1365-2052.2010.02116.x — OMIA Phene_Article / Article\n- 2010. [Molecular basis and applicability in equine color genetics]. Yi Chuan — PubMed:PMID21513164 — OMIA Phene_Article / Article\n- 1946. Genetics of the Palomino horse; confirmation of the Salisbury-Britton hypothesis. J Hered — PubMed:PMID21025138 | DOI:10.1093/oxfordjournals.jhered.a105569 — OMIA Phene_Article / Article\n- 1948. The Abc of color inheritance in horses. Genetics — PubMed:PMID17247268 | DOI:10.1093/genetics/33.1.22 — OMIA Phene_Article / Article\n- 1961. The palomino horse. Genetics — PubMed:PMID13877241 | DOI:10.1093/genetics/46.9.1143 — OMIA Phene_Article / Article\n- (10 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIM:606574 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:227240 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606202 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Quarter Horse (Horse) — Palomino (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Quarter Horse (Horse) — Palomino (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/14832452/","retrieved":"","ref":"PMID 14832452","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":928,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}