{"topic_id":"companion_breed_health_poodle_miniature_omia1366_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_poodle_miniature_omia1366_dog\ncategory: companion-breed-health\ntitle: \"Poodle, Miniature — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/poodle_miniature_omia1366_1366.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 104\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_poodle_miniature_omia1366_dog/01_companion_breed_health_poodle_miniature_omia1366_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Poodle, Miniature — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000743/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Poodle, Miniature — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Poodle, Miniature (Dog)`\n- `Disorder: `\n- `Summary: Genetics Committee of the American College of Veterinary Opthalmologists (2021): a congenital anomaly, which results in a small optic disk diameter and vision loss.Contrast with micropapilla, which may have a similar ophthalmoscopic appearance but without loss of vision.`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article\n- 1971. Case report. Bilateral optic nerve hypoplasia in two dogs.. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article\n- 1976. Bilateral optic nerve hypoplasia in a pup.. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article\n- 1981. Optic nerve hypoplasia in three Miniature Poodles.. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article\n- 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog.. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article\n- 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases.. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article\n- 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study.. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article\n- 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article\n- 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article\n- 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article\n- 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article\n- 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article\n- 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article\n- 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article\n- 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article\n- 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article\n- 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article\n- 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article\n- 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article\n- 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article\n- 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article\n- 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article\n- 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article\n- 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article\n- 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1952. Congenital optic nerve hypoplasia in Collie dogs. Cornell Veterinarian — PubMed:PMID14905886 — OMIA Phene_Article / Article\n- 1971. Case report. Bilateral optic nerve hypoplasia in two dogs. Can Vet J — PubMed:PMID5104935 — OMIA Phene_Article / Article\n- 1976. Bilateral optic nerve hypoplasia in a pup. J Am Vet Med Assoc — PubMed:PMID1245453 — OMIA Phene_Article / Article\n- 1981. Optic nerve hypoplasia in three Miniature Poodles. J Am Vet Med Assoc — PubMed:PMID7204223 — OMIA Phene_Article / Article\n- 1998. What is your diagnosis? Congenital optic nerve hypoplasia in a dog. J Small Anim Pract — PubMed:PMID9494926 — OMIA Phene_Article / Article\n- 2008. Distinctive histopathologic features of canine optic nerve hypoplasia and aplasia: a retrospective review of 13 cases. Vet Ophthalmol — PubMed:PMID18190348 | DOI:10.1111/j.1463-5224.2007.00596.x — OMIA Phene_Article / Article\n- 2020. Optic nerve hypoplasia in miniature poodle dogs: A preliminary genetic and candidate gene association study. Vet Ophthalmol — PubMed:PMID31342635 | DOI:10.1111/vop.12691 — OMIA Phene_Article / Article\n- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:165550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Poodle, Miniature — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Poodle, Miniature — Optic nerve hypoplasia, bilateral (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/14905886/","retrieved":"","ref":"PMID 14905886","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1999,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}