{"topic_id":"companion_breed_health_pomeranian_omia99_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_pomeranian_omia99_dog\ncategory: companion-breed-health\ntitle: \"Pomeranian — Alopecia, generic (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/pomeranian_omia99_99.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_pomeranian_omia99_dog/01_companion_breed_health_pomeranian_omia99_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Pomeranian — Alopecia, generic (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000030/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Pomeranian — Alopecia, generic (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Pomeranian (Dog)`\n- `Disorder: `\n- `Summary: includes references relating to alopecia X, hair cycle arrest`\n- `Defect: yes`\n## Causal variant(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- Variant: chromosome 3; nt change NM_001048133.1:c.-24_32del; pathogenicity class 6 — OMIA Variant / Variant_Phene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1989. A Familial Alopecia. Veterinary Record — PubMed:PMID2609495 — OMIA Phene_Article / Article\n- 1991. Alopecia Associated with Coat Color Dilution in 2 Yorkshire  Terriers, One Saluki, and One Mix-Breed Dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1994. Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal  Alopecia. Veterinary Record — PubMed:PMID8197698 — OMIA Phene_Article / Article\n- 1995. Seasonal flank alopecia in affenpinschers. Journal of Small Animal Practice — PubMed:PMID7650925 — OMIA Phene_Article / Article\n- 1995. Endocrine alopecia in a Miniature Poodle. New Zealand Veterinary Journal — OMIA Phene_Article / Article\n- 1995. Follicular dysplasia of the portuguese water dog. Veterinary Dermatology — OMIA Phene_Article / Article\n- 1996. Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia. Journal of Small Animal Practice — PubMed:PMID8887201 — OMIA Phene_Article / Article\n- 1997. Alopecia in German Shepherds [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 1998. Alopecia X in Chows, Pomeranians and Samoyeds. Veterinary Record — PubMed:PMID9746955 — OMIA Phene_Article / Article\n- 1999. Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback. Veterinary Dermatology — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom. Vet Dermatol — PubMed:PMID34645005 | DOI:10.1046/j.1365-3164.2000.00180.x — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000). Veterinary Dermatology — OMIA Phene_Article / Article\n- (33 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:104000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:104110 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612421 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610753 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300042 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:109200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300710 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Causal variant(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- Variant: chromosome 3; nt change NM_001048133.1:c.-24_32del; pathogenicity class 6 — OMIA Variant / Variant_Phene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1989. A Familial Alopecia. Veterinary Record — PubMed:PMID2609495 — OMIA Phene_Article / Article\n- 1991. Alopecia Associated with Coat Color Dilution in 2 Yorkshire  Terriers, One Saluki, and One Mix-Breed Dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1994. Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal  Alopecia. Veterinary Record — PubMed:PMID8197698 — OMIA Phene_Article / Article\n- 1995. Seasonal flank alopecia in affenpinschers. Journal of Small Animal Practice — PubMed:PMID7650925 — OMIA Phene_Article / Article\n- 1995. Endocrine alopecia in a Miniature Poodle. New Zealand Veterinary Journal — OMIA Phene_Article / Article\n- 1995. Follicular dysplasia of the portuguese water dog. Veterinary Dermatology — OMIA Phene_Article / Article\n- 1996. Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia. Journal of Small Animal Practice — PubMed:PMID8887201 — OMIA Phene_Article / Article\n- 1997. Alopecia in German Shepherds [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 1998. Alopecia X in Chows, Pomeranians and Samoyeds. Veterinary Record — PubMed:PMID9746955 — OMIA Phene_Article / Article\n- 1999. Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback. Veterinary Dermatology — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom. Vet Dermatol — PubMed:PMID34645005 | DOI:10.1046/j.1365-3164.2000.00180.x — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000). Veterinary Dermatology — OMIA Phene_Article / Article\n- (33 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:104000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:104110 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612421 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610753 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300042 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:109200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300710 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Causal variant(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Variant: chromosome 3; nt change NM_001048133.1:c.-24_32del; pathogenicity class 6 — OMIA Variant / Variant_Phene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1989. A Familial Alopecia. Veterinary Record — PubMed:PMID2609495 — OMIA Phene_Article / Article\n- 1991. Alopecia Associated with Coat Color Dilution in 2 Yorkshire  Terriers, One Saluki, and One Mix-Breed Dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1994. Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal  Alopecia. Veterinary Record — PubMed:PMID8197698 — OMIA Phene_Article / Article\n- 1995. Seasonal flank alopecia in affenpinschers. Journal of Small Animal Practice — PubMed:PMID7650925 — OMIA Phene_Article / Article\n- 1995. Endocrine alopecia in a Miniature Poodle. New Zealand Veterinary Journal — OMIA Phene_Article / Article\n- 1995. Follicular dysplasia of the portuguese water dog. Veterinary Dermatology — OMIA Phene_Article / Article\n- 1996. Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia. Journal of Small Animal Practice — PubMed:PMID8887201 — OMIA Phene_Article / Article\n- 1997. Alopecia in German Shepherds [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 1998. Alopecia X in Chows, Pomeranians and Samoyeds. Veterinary Record — PubMed:PMID9746955 — OMIA Phene_Article / Article\n- 1999. Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback. Veterinary Dermatology — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom. Vet Dermatol — PubMed:PMID34645005 | DOI:10.1046/j.1365-3164.2000.00180.x — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000). Veterinary Dermatology — OMIA Phene_Article / Article\n- (33 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:104000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:104110 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612421 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610753 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300042 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:109200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300710 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Causal variant(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Variant: chromosome 3; nt change NM_001048133.1:c.-24_32del; pathogenicity class 6 — OMIA Variant / Variant_Phene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1989. A Familial Alopecia. Veterinary Record — PubMed:PMID2609495 — OMIA Phene_Article / Article\n- 1991. Alopecia Associated with Coat Color Dilution in 2 Yorkshire  Terriers, One Saluki, and One Mix-Breed Dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1994. Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal  Alopecia. Veterinary Record — PubMed:PMID8197698 — OMIA Phene_Article / Article\n- 1995. Seasonal flank alopecia in affenpinschers. Journal of Small Animal Practice — PubMed:PMID7650925 — OMIA Phene_Article / Article\n- 1995. Endocrine alopecia in a Miniature Poodle. New Zealand Veterinary Journal — OMIA Phene_Article / Article\n- 1995. Follicular dysplasia of the portuguese water dog. Veterinary Dermatology — OMIA Phene_Article / Article\n- 1996. Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia. Journal of Small Animal Practice — PubMed:PMID8887201 — OMIA Phene_Article / Article\n- 1997. Alopecia in German Shepherds [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 1998. Alopecia X in Chows, Pomeranians and Samoyeds. Veterinary Record — PubMed:PMID9746955 — OMIA Phene_Article / Article\n- 1999. Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback. Veterinary Dermatology — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom. Vet Dermatol — PubMed:PMID34645005 | DOI:10.1046/j.1365-3164.2000.00180.x — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000). Veterinary Dermatology — OMIA Phene_Article / Article\n- (33 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:104000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:104110 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612421 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610753 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300042 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:109200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300710 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Causal variant(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Variant: chromosome 3; nt change NM_001048133.1:c.-24_32del; pathogenicity class 6 — OMIA Variant / Variant_Phene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1989. A Familial Alopecia. Veterinary Record — PubMed:PMID2609495 — OMIA Phene_Article / Article\n- 1991. Alopecia Associated with Coat Color Dilution in 2 Yorkshire  Terriers, One Saluki, and One Mix-Breed Dog. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article\n- 1994. Fat Absorption in Female Boxer Dogs with Undiagnosed Hormonal  Alopecia. Veterinary Record — PubMed:PMID8197698 — OMIA Phene_Article / Article\n- 1995. Seasonal flank alopecia in affenpinschers. Journal of Small Animal Practice — PubMed:PMID7650925 — OMIA Phene_Article / Article\n- 1995. Endocrine alopecia in a Miniature Poodle. New Zealand Veterinary Journal — OMIA Phene_Article / Article\n- 1995. Follicular dysplasia of the portuguese water dog. Veterinary Dermatology — OMIA Phene_Article / Article\n- 1996. Investigation of the reproductive and growth hormone status of dogs affected by idiopathic recurrent flank alopecia. Journal of Small Animal Practice — PubMed:PMID8887201 — OMIA Phene_Article / Article\n- 1997. Alopecia in German Shepherds [Dutch]. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 1998. Alopecia X in Chows, Pomeranians and Samoyeds. Veterinary Record — PubMed:PMID9746955 — OMIA Phene_Article / Article\n- 1999. Trachyonychia associated with alopecia areata in a Rhodesian Ridgeback. Veterinary Dermatology — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom. Vet Dermatol — PubMed:PMID34645005 | DOI:10.1046/j.1365-3164.2000.00180.x — OMIA Phene_Article / Article\n- 2000. An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000). Veterinary Dermatology — OMIA Phene_Article / Article\n- (33 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:104000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:104110 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:203655 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:612421 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:610753 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300042 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:109200 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:300710 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Pomeranian — Alopecia, generic (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Pomeranian — Alopecia, generic (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/2609495/","retrieved":"","ref":"PMID 2609495","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":3113,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}