{"topic_id":"companion_breed_health_peruvian_paso_horse_inherited_myoclonus_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_peruvian_paso_horse_inherited_myoclonus_horse\ncategory: companion-breed-health\ntitle: \"Peruvian Paso (Horse) — inherited myoclonus (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/peruvian_paso_horse_inherited_myoclonus_1291.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 192\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_peruvian_paso_horse_inherited_myoclonus_horse/01_companion_breed_health_peruvian_paso_horse_inherited_myoclonus_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Peruvian Paso (Horse) — inherited myoclonus (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000689/9796/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Peruvian Paso (Horse) — inherited myoclonus (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Peruvian Paso (Horse)`\n- `Disorder: inherited myoclonus`\n- `Summary: Gundlach et al. (1993) report the occurrence of ... [a] stimulus-induced myoclonus in individual, pure-bred Peruvian Paso horses and an associated, specific deficiency in the density of [3H]strychnine binding to inhibitory glycine receptors sites in spinal cord of these animals. The authors suggest that the disease is similar to inherited myoclonus in Poll Hereford calves (see OMIA:000689-9913 : Hyperekplexia, GLRA1-related in Bos taurus). However, the underlying molecular genetic cause in horses has not been identified, and the disease in horses and may not be associated with variants in the GLRA1 gene.`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1993. Deficit of inhibitory glycine receptors in spinal cord from  Peruvian Pasos - Evidence for an equine form of inherited  myoclonus. Brain Res — PubMed:PMID8313155 | DOI:10.1016/0006-8993(93)90963-n — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:149400 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:138491 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1993. Deficit of inhibitory glycine receptors in spinal cord from  Peruvian Pasos - Evidence for an equine form of inherited  myoclonus. Brain Res — PubMed:PMID8313155 | DOI:10.1016/0006-8993(93)90963-n — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:149400 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:138491 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Peruvian Paso (Horse) — inherited myoclonus (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Peruvian Paso (Horse) — inherited myoclonus (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/8313155/","retrieved":"","ref":"PMID 8313155","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":712,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}