{"topic_id":"companion_breed_health_percheron_horse_omia483_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_percheron_horse_omia483_horse\ncategory: companion-breed-health\ntitle: \"Percheron (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/percheron_horse_omia483_483.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 251\nverification:\n method: substring_match\n claims: 5\n passed: 5\n date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_percheron_horse_omia483_horse/01_companion_breed_health_percheron_horse_omia483_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n title: \"Percheron (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)\"\n url: \"https://omia.org/OMIA000245/9796/\"\n retrieved: \"2026-08-23\"\n ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n needs_review: false\n\nverification_derived:\n method: derived_from_dataset\n source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Percheron (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Percheron (Horse)`\n- `Disorder: `\n- `Mode of inheritance: Morgenthaler et al (2017): in North American horses, the most frequent Curly coat phenotype is described as autosomal dominant (Crd) [Sponenberg, 1990], whereas recessive forms have been reported to segregate in the Quarter Horse, Arabian, Appaloosa, Missouri Fox Trotter, Tennessee Walking Horse, Paint, Morgan and Paso Fino breeds [Sponenberg, 1990] as well as in French Percheron horses [Blakeslee et al., 1943].`\n- `Summary: Information relating to curly coat in horses due to variants in emKRT25/em and emSP6nbsp;/emwas previously listed here but has been moved to gene specific entries [13/02/2026] - seenbsp;a href=../../../../../../OMIA003039/9796/OMIA:003039-9796/a : Curly coat, KRT25-related in Equus caballus (domestic horse) and a href=../../../../../../OMIA002175/9796/OMIA:002175-9796/a : Curly coat, SP6-related in Equus caballus (domestic horse).`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIA molecular-genetics note: For information on likely causal variants in KRT25 and SP6 which were previously listed here see OMIA:003039-9796 : Curly coat, KRT25-related in Equus caballus (domestic horse) and OMIA:002175-9796 : Curly coat, SP6-related in Equus caballus (domestic horse).\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- 1940. Inheritance of curliness in the horse. C.R. (Doklady) Academy of Science U.R.S.S., N.S. — OMIA Phene_Article / Article\n- 1990. Dominant Curly Coat in Horses. Genetics Selection Evolution — OMIA Phene_Article / Article\n- 2016. Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet — PubMed:PMID26662214 | DOI:10.1111/age.12393 — OMIA Phene_Article / Article\n- 2017. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol — PubMed:PMID29141579 | DOI:10.1186/s12711-017-0359-5 — OMIA Phene_Article / Article\n- 1989. Myth and mystery: the curly horse in America. New York: C.S. Fund Inc. — OMIA Phene_Article / Article\n- 1943. Curly coat of horses. Journal of Heredity — OMIA Phene_Article / Article\n- 2018. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep — PubMed:PMID29686323 | DOI:10.1038/s41598-018-24865-3 — OMIA Phene_Article / Article\n- 2024. Horse allergy: Curly Horses can mediate immune tolerance. Pneumologie — PubMed:PMID37827498 | DOI:10.1055/a-2101-9533 — OMIA Phene_Article / Article\n- 2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIM:608245 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Percheron (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Percheron (Horse) — Curly coat (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/26662214/","retrieved":"","ref":"PMID 26662214","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":847,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}