{"topic_id":"companion_breed_health_new_zealand_white_rabbit_omia6041_rabbit","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_new_zealand_white_rabbit_omia6041_rabbit\ncategory: companion-breed-health\ntitle: \"New Zealand White (Rabbit) — Cerebral palsy, RHOB-related (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/new_zealand_white_rabbit_omia6041_6041.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 91\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_new_zealand_white_rabbit_omia6041_rabbit/01_companion_breed_health_new_zealand_white_rabbit_omia6041_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"New Zealand White (Rabbit) — Cerebral palsy, RHOB-related (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002865/9986/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# New Zealand White (Rabbit) — Cerebral palsy, RHOB-related (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: New Zealand White (Rabbit)`\n- `Disorder: `\n- `Summary: Wu et al. (2024) created a rabbit model using the SpG-BE4max system to mimic a de novo RhoB p.S73F mutation associated with cerebral palsy in humans. This study involves genetically modified organisms (GMO).brbr`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398298915 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2024. The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis. EMBO Mol Med — PubMed:PMID39080495 | DOI:10.1038/s44321-024-00113-2 — OMIA Phene_Article / Article\n","sources":["companion-breed-health — New Zealand White (Rabbit) — Cerebral palsy, RHOB-related (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"New Zealand White (Rabbit) — Cerebral palsy, RHOB-related (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/39080495/","retrieved":"","ref":"PMID 39080495","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":445,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}