{"topic_id":"companion_breed_health_morgan_horse_tobiano_sabino_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_morgan_horse_tobiano_sabino_horse\ncategory: companion-breed-health\ntitle: \"Morgan (Horse) — Tobiano, Sabino (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/morgan_horse_tobiano_sabino_2710.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 254\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_morgan_horse_tobiano_sabino_horse/01_companion_breed_health_morgan_horse_tobiano_sabino_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Morgan (Horse) — Tobiano, Sabino (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000209/9796/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Morgan (Horse) — Tobiano, Sabino (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Morgan (Horse)`\n- `Disorder: Tobiano, Sabino`\n- `Mode of inheritance: Autosomal dominant`\n- `Defect: yes`\n- `Prevalence: Druml et al. (2018) reported that the SB1 variant is present in three breeds (Haflinger, 14 out of 98; Noriker, four out of 189; Lipizzan one out of 329) . . . None of the SB1/sb1-carrier horses met the criteria defining the Sabino1 pattern according to current applied protocols. Esdaile et al. (2021): The estimated allele frequency of W13 in the American Miniature Horse was 0.0063 (79 N/N, 1 W13/N) and the allele was not detected in a random sample (n = 59) of Shetland ponies. In the same study 14 out of 19 all-white unregistered Shetland ponies were heterozygous for the W13 variant.`\n- `Gen test: McFadden et al. (2024, PMID:nbsp;a href=https://pubmed.ncbi.nlm.nih.gov/3833816038338160/a) propose emKIT/emnbsp;variants be reported as phased genotypes or the separation of different loci to more accurately report genotypes.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: c-kit (Entrez Gene ID 5430480) — OMIA Phene_Gene / GeneSynonym\n- OMIA molecular-genetics note: Using the comparative candidate-gene strategy (based on the KIT gene being associated with similar coat-colour-phenotypes in humans and pigs), Brooks and Bailey (2005) sequenced the KIT gene in horses of each of the three genotypes at a Sabino-spotting locus they called Sabino 1, and identified a splice variant (omia.variant:885), namely \"a base substitution for T with A in intron 16, 1037 bases f…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1978. Linkage of tobiano coat spotting and albumin markers in a pony family. Journal of Heredity — PubMed:PMID569673 — OMIA Phene_Article / Article\n- 2002. A PCR-RFLP for KIT associated with tobiano spotting pattern in horses. Animal Genetics — PubMed:PMID12139510 — OMIA Phene_Article / Article\n- 2005. Exon skipping in the KIT gene causes a Sabino spotting pattern in horses. Mamm Genome — PubMed:PMID16284805 | DOI:10.1007/s00335-005-2472-y — OMIA Phene_Article / Article\n- 2004. Genetic mapping of dominant white (W), a homozygous lethal condition in the horse (Equus caballus). Journal of Animal Breeding and Genetics — OMIA Phene_Article / Article\n- 2007. A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses. Cytogenet Genome Res — PubMed:PMID18253033 | DOI:10.1159/000112065 — OMIA Phene_Article / Article\n- 2008. An equine chromosome 3 inversion is associated with the tobiano spotting pattern in German horse breeds. Anim Genet — PubMed:PMID18410476 | DOI:10.1111/j.1365-2052.2008.01715.x — OMIA Phene_Article / Article\n- 2007. Allelic heterogeneity at the equine KIT locus in dominant white (W) horses. PLoS Genet — PubMed:PMID17997609 | DOI:10.1371/journal.pgen.0030195 — OMIA Phene_Article / Article\n- 1969. Lethal dominant white in horses. J Hered — PubMed:PMID5816567 — OMIA Phene_Article / Article\n- 2008. Genetic analysis of white facial and leg markings in the Swiss Franches-Montagnes Horse Breed. J Hered — PubMed:PMID18296388 | DOI:10.1093/jhered/esm115 — OMIA Phene_Article / Article\n- 2009. Seven novel KIT mutations in horses with white coat colour phenotypes. Anim Genet — PubMed:PMID19456317 | DOI:10.1111/j.1365-2052.2009.01893.x — OMIA Phene_Article / Article\n- 2009. Haematological parameters are normal in dominant white Franches-Montagnes horses carrying a KIT mutation. Vet J — PubMed:PMID19362501 | DOI:10.1016/j.tvjl.2009.02.017 — OMIA Phene_Article / Article\n- 2010. An unexpected advantage of whiteness in horses: the most horsefly-proof horse has a depolarizing white coat. Proc Biol Sci — PubMed:PMID20129982 | DOI:10.1098/rspb.2009.2202 — OMIA Phene_Article / Article\n- (38 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:172800 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:164920 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Morgan (Horse) — Tobiano, Sabino (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Morgan (Horse) — Tobiano, Sabino (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/569673/","retrieved":"","ref":"PMID 569673","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1082,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}