{"topic_id":"companion_breed_health_miniature_schnauzer_omia1188_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_miniature_schnauzer_omia1188_dog\ncategory: companion-breed-health\ntitle: \"Miniature Schnauzer — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/miniature_schnauzer_omia1188_1188.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 188\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_miniature_schnauzer_omia1188_dog/01_companion_breed_health_miniature_schnauzer_omia1188_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Miniature Schnauzer — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000620/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Miniature Schnauzer — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Miniature Schnauzer (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Multifactorial`\n- `Defect: yes`\n- `Gen test: A pre-test, based on the results of Shearin et al. (2012) is available from Antagene: http://www.antagene.com/en/commander/histiocytic-sarcoma-pre-test. Given the results reported by Asada et al. (2019), namely that The mutation was detected in [only] 26 of 64 [affected] dogs (41%) and their conclusion that HS cells might acquire insAT in the TP53 gene during development of metastasis, but insAT was not a prognostic factor in canine HS, it would seem that insAT is not a useful marker. It has, therefore, been removed from the OMIA table of likely causal variants.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: P53 (Entrez Gene ID 403869) — OMIA Phene_Gene / GeneSynonym\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1993. Disseminated malignant histiocytosis in a Golden Retriever -  clinicopathologic, ultrastructural, and immunohistochemical  findings. Vet Pathol — PubMed:PMID8333107 | DOI:10.1177/030098589303000306 — OMIA Phene_Article / Article\n- 1995. Inheritance of histiocytosis in Bernese mountain dogs. Journal of Small Animal Practice — PubMed:PMID7783441 — OMIA Phene_Article / Article\n- 1995. Systemic histiocytosis in the Bernese mountain dog. Journal of Small Animal Practice — PubMed:PMID7650919 — OMIA Phene_Article / Article\n- 1996. Malignant histiocytosis in three Bernese Mountain dogs. Veterinary Record — PubMed:PMID8735262 — OMIA Phene_Article / Article\n- 2009. Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered — PubMed:PMID19531730 | DOI:10.1093/jhered/esp039 — OMIA Phene_Article / Article\n- 2010. Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec — PubMed:PMID20154310 | DOI:10.1136/vr.b4756 — OMIA Phene_Article / Article\n- 2011. Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer — PubMed:PMID21615919 | DOI:10.1186/1471-2407-11-201 — OMIA Phene_Article / Article\n- 2006. Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Am J Vet Res — PubMed:PMID16579756 | DOI:10.2460/ajvr.67.4.633 — OMIA Phene_Article / Article\n- 2012. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol Biomarkers Prev — PubMed:PMID22623710 | DOI:10.1158/1055-9965.EPI-12-0190-T — OMIA Phene_Article / Article\n- 2013. Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci — PubMed:PMID23738139 | DOI:10.1155/2013/941275 — OMIA Phene_Article / Article\n- 2013. Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One — PubMed:PMID23936488 | DOI:10.1371/journal.pone.0071094 — OMIA Phene_Article / Article\n- 2015. Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). J Vet Intern Med — PubMed:PMID25711602 | DOI:10.1111/jvim.12554 — OMIA Phene_Article / Article\n- (69 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:191170 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Miniature Schnauzer — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Miniature Schnauzer — Histiocytosis, malignant (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/8333107/","retrieved":"","ref":"PMID 8333107","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":939,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}