{"topic_id":"companion_breed_health_mini_silver_omia2943_rabbit","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_mini_silver_omia2943_rabbit\ncategory: companion-breed-health\ntitle: \"Mini Silver — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/mini_silver_omia2943_2943.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 177\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_mini_silver_omia2943_rabbit/01_companion_breed_health_mini_silver_omia2943_rabbit.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Mini Silver — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000201/9986/\"\n  retrieved: \"2026-08-23\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Mini Silver — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Mini Silver`\n- `Disorder: `\n- `Mode of inheritance: Autosomal`\n- `Defect: no`\n- `Prevalence: Letko et al. (2020) genotyped 49 rabbits with different coat colours . . . . Out of 19 black and tan rabbits analysed, 17 carried the deletion in a homozygous state. The remaining two black and tan rabbits were heterozygous for the deletion but also heterozygous for the single base insertion, causing recessive black and thus presumably compound heterozygous a^t/a. As the a allele is recessive to a^t, rabbits with an a^t/a genotype are phenotypically black and tan. None of the 30 rabbits that were not black and tan carried the deletion in a homozygous state.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 4215581 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2010. Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour. Genomics — PubMed:PMID20004240 | DOI:10.1016/j.ygeno.2009.11.003 — OMIA Phene_Article / Article\n- 1953. [Studies on the coat markings of wild rabbits; a contribution to the mechanism of the agouti factor.]. Z Indukt Abstamm Vererbungsl — PubMed:PMID13091004 — OMIA Phene_Article / Article\n- 1958. Genetic studies of the rabbit. Bibliographia Genetica — OMIA Phene_Article / Article\n- 2019. Multiple conserved elements structuring inverted repeats in the mammalian coat color-related gene Asip. Zoolog Sci — PubMed:PMID31116535 | DOI:10.2108/zs180081 — OMIA Phene_Article / Article\n- 2020. A deletion spanning the promoter and first exon of the hair cycle-specific ASIP transcript isoform in black and tan rabbits. Anim Genet — PubMed:PMID31729778 | DOI:10.1111/age.12881 — OMIA Phene_Article / Article\n- 2023. A genome-wide association study of coat color in Chinese Rex rabbits. Front Vet Sci — PubMed:PMID37655262 | DOI:10.3389/fvets.2023.1184764 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:611742 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600201 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Mini Silver — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Mini Silver — Coat colour, agouti (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/20004240/","retrieved":"","ref":"PMID 20004240","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":764,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}