{"topic_id":"companion_breed_health_leonberger_omia1785_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_leonberger_omia1785_dog\ncategory: companion-breed-health\ntitle: \"Leonberger — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/leonberger_omia1785_1785.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 92\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_leonberger_omia1785_dog/01_companion_breed_health_leonberger_omia1785_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Leonberger — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001040/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Leonberger — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Leonberger (Dog)`\n- `Disorder: `\n- `Defect: yes`\n- `Prevalence: Meurs et al. (2019): the variant was significantly associated with the arrhythmia in the Rhodesian Ridgeback family (p = 0.001) and was identified as homozygous in the affected offspring and heterozygous in both of the parents.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 388245149 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Meurs et al. (2019): \"A single missense G/A variant in the QIL1 [also called MICOS13, C20H19ORF70] gene was associated with the cardiac arrhythmia (p < 0.0001). The variant was predicted to change the amino acid from conserved Glycine to Serine and to be deleterious.\"\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1994. Inherited ventricular arrhythmias and sudden death in German Shepherd dogs. Journal of the American College of Cardiology — PubMed:PMID8006271 — OMIA Phene_Article / Article\n- 1996. Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death. Journal of Cardiovascular Electrophysiology — PubMed:PMID8867296 — OMIA Phene_Article / Article\n- 1996. Triggered activity as a mechanism for inherited ventricular arrhythmias in German Shepherd dogs. Journal of the American College of Cardiology — PubMed:PMID8626969 — OMIA Phene_Article / Article\n- 1997. Heterogeneous sympathetic innervation in german shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death. Circulation — PubMed:PMID9286967 — OMIA Phene_Article / Article\n- 1999. Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death. Cardiovascular Research — PubMed:PMID10434997 — OMIA Phene_Article / Article\n- 1999. Familial ventricular arrhythmias in boxers. Journal of Veterinary Internal Medicine — PubMed:PMID10499727 — OMIA Phene_Article / Article\n- 2000. Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: Abnormal response to potassium channel blockers. Journal of the American College of Cardiology — PubMed:PMID10987623 — OMIA Phene_Article / Article\n- 2000. beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias. Cardiovascular Research — PubMed:PMID11054468 — OMIA Phene_Article / Article\n- 2004. Mechanisms of alpha-adrenergic potentiation of ventricular arrhythmias in dogs with inherited arrhythmic sudden death. Cardiovasc Res — PubMed:PMID14985068 | DOI:10.1016/j.cardiores.2003.12.025 — OMIA Phene_Article / Article\n- 2003. Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death. Circulation — PubMed:PMID12939224 | DOI:10.1161/01.CIR.0000086461.86642.22 — OMIA Phene_Article / Article\n- 2005. Regional dispersion of L-type calcium current in ventricular myocytes of German shepherd dogs with lethal cardiac arrhythmias. Heart Rhythm — PubMed:PMID15851292 | DOI:10.1016/j.hrthm.2004.10.041 — OMIA Phene_Article / Article\n- 2011. Implantable cardioverter-defibrillator in a German shepherd dog with ventricular arrhythmias. J Vet Cardiol — PubMed:PMID21849269 | DOI:10.1016/j.jvc.2011.04.006 — OMIA Phene_Article / Article\n- (16 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:618329 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:616658 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Leonberger — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Leonberger — Ventricular arrhythmias and sudden death (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/8006271/","retrieved":"","ref":"PMID 8006271","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":959,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}