{"topic_id":"companion_breed_health_korat_atherosclerosis_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_korat_atherosclerosis_cat\ncategory: companion-breed-health\ntitle: \"Korat — atherosclerosis (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/korat_atherosclerosis_6461.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 257\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_korat_atherosclerosis_cat/01_companion_breed_health_korat_atherosclerosis_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Korat — atherosclerosis (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000499/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Korat — atherosclerosis (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Korat (Cat)`\n- `Disorder: atherosclerosis`\n- `Clin feat: Karkamo et al. (2021): report the clinical and histopathological findings in two related cats of the Korat breed that presented with clinical signs of heart failure. In both cases, the clinical signs appeared in adulthood, were progressive and led to death. Affected cats hadnbsp;markedly elevated plasma total cholesterol levels.brKarkamo et al. (2025) report that cats that are heterozygote for a likely causal variand identified bynbsp;(Hytönen et al., 2024) are asymptomatic without alterations in plasma cholesterol levels.`\n- `Defect: yes`\n- `Pathology: Karkamo et al. (2021): At necropsy [of affected Korat cats], severe atherosclerotic lesions were present in large and medium-sized arteries and were characterized by the formation of a fibrous cap and a lipid core, which contained a particularly large accumulation of cholesterol crystals, as indicated by the presence of many cholesterol clefts.`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398299026 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Hytönen et al. (2024) conducted whole genome sequencing and identified a homozygous XM_003981898.6:c.2406G&gt;A (mRNA) / XM_003981898.6:c.2274G&gt;A (CDS) variant (omia.variant:1817) in affected Korat cats.\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2021. Severe spontaneous atherosclerosis in two Korat breed cats is comparable to human atherosclerosis. J Comp Pathol — PubMed:PMID34686278 | DOI:10.1016/j.jcpa.2021.08.006 — OMIA Phene_Article / Article\n- 2025. Heterozygous Korat cats with LDL receptor mutation are asymptomatic and normolipidemic. Res Vet Sci — PubMed:PMID40609308 | DOI:10.1016/j.rvsc.2025.105784 — OMIA Phene_Article / Article\n- 2024. A feline model of human LDLR-related atherosclerosis. bioRxiv — DOI:10.1101/2024.12.04.626782 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:143890 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606945 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Korat — atherosclerosis (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Korat — atherosclerosis (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/34686278/","retrieved":"","ref":"PMID 34686278","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":702,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}