{"topic_id":"companion_breed_health_keeshond_omia1723_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_keeshond_omia1723_dog\ncategory: companion-breed-health\ntitle: \"Keeshond — Tetralogy of Fallot (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/keeshond_omia1723_1723.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_keeshond_omia1723_dog/01_companion_breed_health_keeshond_omia1723_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Keeshond — Tetralogy of Fallot (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000994/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Keeshond — Tetralogy of Fallot (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Keeshond (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Multifactorial`\n- `Summary: see conotruncal heart malformations in the dog`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1995. Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID7494990 — OMIA Phene_Article / Article\n- 1997. Retrospective study of congenital heart defects in 151 dogs. Journal of Small Animal Practice — PubMed:PMID9097239 — OMIA Phene_Article / Article\n- 1998. Open-heart correction of tetralogy of fallot in an acyanotic dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 1999. Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot. Journal of Veterinary Medical Science — PubMed:PMID10535516 — OMIA Phene_Article / Article\n- 2001. Open surgical repair of tetralogy of Fallot in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11700706 — OMIA Phene_Article / Article\n- 2009. Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF).. J Anim Breed Genet — PubMed:PMID19630881 | DOI:10.1111/j.1439-0388.2008.00776.x — OMIA Phene_Article / Article\n- 2016. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014).. J Am Vet Med Assoc — PubMed:PMID27700266 | DOI:10.2460/javma.249.8.909 — OMIA Phene_Article / Article\n- 2024. Complex tetralogy of Fallot in an acyanotic adult dog.. CASE (Phila) — PubMed:PMID38524971 | DOI:10.1016/j.case.2023.12.010 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:187500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:187501 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:239711 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1995. Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID7494990 — OMIA Phene_Article / Article\n- 1997. Retrospective study of congenital heart defects in 151 dogs. Journal of Small Animal Practice — PubMed:PMID9097239 — OMIA Phene_Article / Article\n- 1998. Open-heart correction of tetralogy of fallot in an acyanotic dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 1999. Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot. Journal of Veterinary Medical Science — PubMed:PMID10535516 — OMIA Phene_Article / Article\n- 2001. Open surgical repair of tetralogy of Fallot in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11700706 — OMIA Phene_Article / Article\n- 2009. Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). J Anim Breed Genet — PubMed:PMID19630881 | DOI:10.1111/j.1439-0388.2008.00776.x — OMIA Phene_Article / Article\n- 2016. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc — PubMed:PMID27700266 | DOI:10.2460/javma.249.8.909 — OMIA Phene_Article / Article\n- 2024. Complex tetralogy of Fallot in an acyanotic adult dog. CASE (Phila) — PubMed:PMID38524971 | DOI:10.1016/j.case.2023.12.010 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:187500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:187501 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:239711 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1995. Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID7494990 — OMIA Phene_Article / Article\n- 1997. Retrospective study of congenital heart defects in 151 dogs. Journal of Small Animal Practice — PubMed:PMID9097239 — OMIA Phene_Article / Article\n- 1998. Open-heart correction of tetralogy of fallot in an acyanotic dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 1999. Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot. Journal of Veterinary Medical Science — PubMed:PMID10535516 — OMIA Phene_Article / Article\n- 2001. Open surgical repair of tetralogy of Fallot in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11700706 — OMIA Phene_Article / Article\n- 2009. Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). J Anim Breed Genet — PubMed:PMID19630881 | DOI:10.1111/j.1439-0388.2008.00776.x — OMIA Phene_Article / Article\n- 2016. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc — PubMed:PMID27700266 | DOI:10.2460/javma.249.8.909 — OMIA Phene_Article / Article\n- 2024. Complex tetralogy of Fallot in an acyanotic adult dog. CASE (Phila) — PubMed:PMID38524971 | DOI:10.1016/j.case.2023.12.010 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:187500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:187501 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:239711 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1995. Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID7494990 — OMIA Phene_Article / Article\n- 1997. Retrospective study of congenital heart defects in 151 dogs. Journal of Small Animal Practice — PubMed:PMID9097239 — OMIA Phene_Article / Article\n- 1998. Open-heart correction of tetralogy of fallot in an acyanotic dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 1999. Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot. Journal of Veterinary Medical Science — PubMed:PMID10535516 — OMIA Phene_Article / Article\n- 2001. Open surgical repair of tetralogy of Fallot in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11700706 — OMIA Phene_Article / Article\n- 2009. Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). J Anim Breed Genet — PubMed:PMID19630881 | DOI:10.1111/j.1439-0388.2008.00776.x — OMIA Phene_Article / Article\n- 2016. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc — PubMed:PMID27700266 | DOI:10.2460/javma.249.8.909 — OMIA Phene_Article / Article\n- 2024. Complex tetralogy of Fallot in an acyanotic adult dog. CASE (Phila) — PubMed:PMID38524971 | DOI:10.1016/j.case.2023.12.010 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:187500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:187501 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:239711 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1995. Palliative treatment of tetralogy of fallot in a dog using a ptfe (polytetrafluorethylene) vascular graft [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID7494990 — OMIA Phene_Article / Article\n- 1997. Retrospective study of congenital heart defects in 151 dogs. Journal of Small Animal Practice — PubMed:PMID9097239 — OMIA Phene_Article / Article\n- 1998. Open-heart correction of tetralogy of fallot in an acyanotic dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 1999. Balloon dilation of right ventricular outflow tract in a dog with tetralogy of Fallot. Journal of Veterinary Medical Science — PubMed:PMID10535516 — OMIA Phene_Article / Article\n- 2001. Open surgical repair of tetralogy of Fallot in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11700706 — OMIA Phene_Article / Article\n- 2009. Genetic screening of the canine zinc finger protein multitype 2 (cZFPM2) gene in dogs with tetralogy of Fallot (TOF). J Anim Breed Genet — PubMed:PMID19630881 | DOI:10.1111/j.1439-0388.2008.00776.x — OMIA Phene_Article / Article\n- 2016. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc — PubMed:PMID27700266 | DOI:10.2460/javma.249.8.909 — OMIA Phene_Article / Article\n- 2024. Complex tetralogy of Fallot in an acyanotic adult dog. CASE (Phila) — PubMed:PMID38524971 | DOI:10.1016/j.case.2023.12.010 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:187500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:187501 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:239711 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Keeshond — Tetralogy of Fallot (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Keeshond — Tetralogy of Fallot (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/7494990/","retrieved":"","ref":"PMID 7494990","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2307,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}