{"topic_id":"companion_breed_health_irish_setter_omia5594_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_irish_setter_omia5594_dog\ncategory: companion-breed-health\ntitle: \"Irish Setter — Lissencephaly, generic (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/irish_setter_omia5594_5594.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_irish_setter_omia5594_dog/01_companion_breed_health_irish_setter_omia5594_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Irish Setter — Lissencephaly, generic (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002771/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Irish Setter — Lissencephaly, generic (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Irish Setter (Dog)`\n- `Disorder: `\n- `Summary: See also a href=https://omia.org/OMIA001867/9615/OMIA:001867-9615/a : Lissencephaly and cerebellar hypoplasia, RELN-related in Canis lupus familiaris`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1976. Lissencephaly in two Lhasa Apso dogs.. J Am Vet Med Assoc — PubMed:PMID956022 — OMIA Phene_Article / Article\n- 1976. Lissencephaly in Lhasa Apso dogs.. J Am Vet Med Assoc — PubMed:PMID1033927 — OMIA Phene_Article / Article\n- 2011. Clinical and MRI findings of lissencephaly in a mixed breed dog.. J Vet Med Sci — PubMed:PMID21685716 | DOI:10.1292/jvms.11-0117 — OMIA Phene_Article / Article\n- 2002. Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos.. Vet Radiol Ultrasound — PubMed:PMID12174995 | DOI:10.1111/j.1740-8261.2002.tb01013.x — OMIA Phene_Article / Article\n- 2016. Lissencephaly in an adult Australian Kelpie.. Aust Vet J — PubMed:PMID27021891 | DOI:10.1111/avj.12423 — OMIA Phene_Article / Article\n- 2020. Lissencephaly in Shih Tzu dogs.. Acta Vet Scand — PubMed:PMID32563254 | DOI:10.1186/s13028-020-00528-0 — OMIA Phene_Article / Article\n- 2017. Lissencephaly in a Pekingese.. J Vet Med Sci — PubMed:PMID28819088 | DOI:10.1292/jvms.17-0271 — OMIA Phene_Article / Article\n- 2009. Development of the Nervous System: Malformations.. Veterinary neuroanatomy and clinical neurology. 3rd edn. Saunders Elsevier, St Louis — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1976. Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID956022 — OMIA Phene_Article / Article\n- 1976. Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID1033927 — OMIA Phene_Article / Article\n- 2011. Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci — PubMed:PMID21685716 | DOI:10.1292/jvms.11-0117 — OMIA Phene_Article / Article\n- 2002. Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound — PubMed:PMID12174995 | DOI:10.1111/j.1740-8261.2002.tb01013.x — OMIA Phene_Article / Article\n- 2016. Lissencephaly in an adult Australian Kelpie. Aust Vet J — PubMed:PMID27021891 | DOI:10.1111/avj.12423 — OMIA Phene_Article / Article\n- 2020. Lissencephaly in Shih Tzu dogs. Acta Vet Scand — PubMed:PMID32563254 | DOI:10.1186/s13028-020-00528-0 — OMIA Phene_Article / Article\n- 2017. Lissencephaly in a Pekingese. J Vet Med Sci — PubMed:PMID28819088 | DOI:10.1292/jvms.17-0271 — OMIA Phene_Article / Article\n- 2009. Development of the Nervous System: Malformations. Veterinary neuroanatomy and clinical neurology. 3rd edn. Saunders Elsevier, St Louis — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID956022 — OMIA Phene_Article / Article\n- 1976. Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID1033927 — OMIA Phene_Article / Article\n- 2011. Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci — PubMed:PMID21685716 | DOI:10.1292/jvms.11-0117 — OMIA Phene_Article / Article\n- 2002. Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound — PubMed:PMID12174995 | DOI:10.1111/j.1740-8261.2002.tb01013.x — OMIA Phene_Article / Article\n- 2016. Lissencephaly in an adult Australian Kelpie. Aust Vet J — PubMed:PMID27021891 | DOI:10.1111/avj.12423 — OMIA Phene_Article / Article\n- 2020. Lissencephaly in Shih Tzu dogs. Acta Vet Scand — PubMed:PMID32563254 | DOI:10.1186/s13028-020-00528-0 — OMIA Phene_Article / Article\n- 2017. Lissencephaly in a Pekingese. J Vet Med Sci — PubMed:PMID28819088 | DOI:10.1292/jvms.17-0271 — OMIA Phene_Article / Article\n- 2009. Development of the Nervous System: Malformations. Veterinary neuroanatomy and clinical neurology. 3rd edn. Saunders Elsevier, St Louis — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID956022 — OMIA Phene_Article / Article\n- 1976. Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID1033927 — OMIA Phene_Article / Article\n- 2011. Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci — PubMed:PMID21685716 | DOI:10.1292/jvms.11-0117 — OMIA Phene_Article / Article\n- 2002. Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound — PubMed:PMID12174995 | DOI:10.1111/j.1740-8261.2002.tb01013.x — OMIA Phene_Article / Article\n- 2016. Lissencephaly in an adult Australian Kelpie. Aust Vet J — PubMed:PMID27021891 | DOI:10.1111/avj.12423 — OMIA Phene_Article / Article\n- 2020. Lissencephaly in Shih Tzu dogs. Acta Vet Scand — PubMed:PMID32563254 | DOI:10.1186/s13028-020-00528-0 — OMIA Phene_Article / Article\n- 2017. Lissencephaly in a Pekingese. J Vet Med Sci — PubMed:PMID28819088 | DOI:10.1292/jvms.17-0271 — OMIA Phene_Article / Article\n- 2009. Development of the Nervous System: Malformations. Veterinary neuroanatomy and clinical neurology. 3rd edn. Saunders Elsevier, St Louis — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1976. Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID956022 — OMIA Phene_Article / Article\n- 1976. Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc — PubMed:PMID1033927 — OMIA Phene_Article / Article\n- 2011. Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci — PubMed:PMID21685716 | DOI:10.1292/jvms.11-0117 — OMIA Phene_Article / Article\n- 2002. Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound — PubMed:PMID12174995 | DOI:10.1111/j.1740-8261.2002.tb01013.x — OMIA Phene_Article / Article\n- 2016. Lissencephaly in an adult Australian Kelpie. Aust Vet J — PubMed:PMID27021891 | DOI:10.1111/avj.12423 — OMIA Phene_Article / Article\n- 2020. Lissencephaly in Shih Tzu dogs. Acta Vet Scand — PubMed:PMID32563254 | DOI:10.1186/s13028-020-00528-0 — OMIA Phene_Article / Article\n- 2017. Lissencephaly in a Pekingese. J Vet Med Sci — PubMed:PMID28819088 | DOI:10.1292/jvms.17-0271 — OMIA Phene_Article / Article\n- 2009. Development of the Nervous System: Malformations. Veterinary neuroanatomy and clinical neurology. 3rd edn. Saunders Elsevier, St Louis — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Irish Setter — Lissencephaly, generic (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Irish Setter — Lissencephaly, generic (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/956022/","retrieved":"","ref":"PMID 956022","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1628,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}