{"topic_id":"companion_breed_health_german_longhaired_pointer_omia4590_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_german_longhaired_pointer_omia4590_dog\ncategory: companion-breed-health\ntitle: \"German Longhaired Pointer — Thyroid follicular cell carcinoma, predisposition to (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/german_longhaired_pointer_omia4590_4590.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 181\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_german_longhaired_pointer_omia4590_dog/01_companion_breed_health_german_longhaired_pointer_omia4590_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"German Longhaired Pointer — Thyroid follicular cell carcinoma, predisposition to (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002380/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# German Longhaired Pointer — Thyroid follicular cell carcinoma, predisposition to (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: German Longhaired Pointer (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Probably autosomal recessive`\n- `Summary: Yu et al. (2021) described familial thyroid follicular cell carcinomas in Dutch German longhaired pointers (GLPs). Yu et al. (2021) investigated the genetic causes of the disease using a combined approach of genome-wide association study and runs of homozygosity (ROH) analysis based on 170k SNP array genotype data and whole-genome sequences.`\n- `Clin feat: Yu et al. (2021): The age of diagnosis ranged between 4.5 and 13.5 years, and 76% of cases were diagnosed before 10 years of age, implying an early onset of disease.`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 403521 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2021. Deleterious mutations in the TPO gene associated with familial thyroid follicular cell carcinoma in Dutch German longhaired pointers. Genes (Basel) — PubMed:PMID34209805 | DOI:10.3390/genes12070997 — OMIA Phene_Article / Article\n- 2022. Familial follicular cell thyroid carcinomas in a large number of Dutch German longhaired pointers. Vet Comp Oncol — PubMed:PMID34464021 | DOI:10.1111/vco.12769 — OMIA Phene_Article / Article\n- 2022. A recurrent somatic missense mutation in GNAS gene identified in familial thyroid follicular cell carcinomas in German longhaired pointer dogs. BMC Genomics — PubMed:PMID36151521 | DOI:10.1186/s12864-022-08885-y — OMIA Phene_Article / Article\n- 2025. Comparative genomic and clinicopathological analysis uncovers contrasting molecular profiles of canine and human thyroid carcinomas. Commun Biol — PubMed:PMID41353477 | DOI:10.1038/s42003-025-09225-y — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:606765 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:603386 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:188550 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:605642 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — German Longhaired Pointer — Thyroid follicular cell carcinoma, predisposition to (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"German Longhaired Pointer — Thyroid follicular cell carcinoma, predisposition to (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/34209805/","retrieved":"","ref":"PMID 34209805","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":735,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}