{"topic_id":"companion_breed_health_french_bulldog_omia2243_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_french_bulldog_omia2243_dog\ncategory: companion-breed-health\ntitle: \"French Bulldog — Syringomyelia (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/french_bulldog_omia2243_2243.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 84\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_french_bulldog_omia2243_dog/01_companion_breed_health_french_bulldog_omia2243_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"French Bulldog — Syringomyelia (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000965/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# French Bulldog — Syringomyelia (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: French Bulldog (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Multifactorial`\n- `Summary: See also a href=http://https//omia.org/OMIA001861/9615/OMIA:001861-9615/a : Chiari malformation Type I with syringomyelia in Canis lupus familiaris.brnbsp;`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article\n- 1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article\n- 2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article\n- 2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article\n- 2008. Syringomyelia in cavalier King Charles spaniels.. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article\n- 2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting.. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article\n- 2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia.. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article\n- 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain.. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article\n- 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia.. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article\n- 2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog.. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article\n- 2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel.. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article\n- (46 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article\n- 1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article\n- 2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article\n- 2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article\n- 2008. Syringomyelia in cavalier King Charles spaniels. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article\n- 2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article\n- 2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article\n- 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article\n- 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article\n- 2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article\n- 2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article\n- (46 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article\n- 1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article\n- 2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article\n- 2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article\n- 2008. Syringomyelia in cavalier King Charles spaniels. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article\n- 2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article\n- 2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article\n- 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article\n- 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article\n- 2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article\n- 2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article\n- (46 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article\n- 1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article\n- 2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article\n- 2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article\n- 2008. Syringomyelia in cavalier King Charles spaniels. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article\n- 2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article\n- 2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article\n- 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article\n- 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article\n- 2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article\n- 2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article\n- (46 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1965. Spinal dysraphism in the dog, with comments on syringomylia. Pathologia Veterinaria — PubMed:PMID5893238 — OMIA Phene_Article / Article\n- 1996. Syringomyelia and hydrocephalus in a dog. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article\n- 2000. Syringohydromyelia in Cavalier King Charles spaniels. Journal of the American Animal Hospital Association — PubMed:PMID10667404 — OMIA Phene_Article / Article\n- 2000. Syringomyelia and hydromyelia in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article\n- 2000. Magnetic resonance imaging of syringomyelia in five dogs. Journal of Small Animal Practice — PubMed:PMID11002940 — OMIA Phene_Article / Article\n- 2008. Syringomyelia in cavalier King Charles spaniels. Vet Rec — PubMed:PMID18326849 — OMIA Phene_Article / Article\n- 2008. Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J — PubMed:PMID18271823 | DOI:10.1111/j.1751-0813.2007.00247.x — OMIA Phene_Article / Article\n- 2008. Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res — PubMed:PMID18167092 | DOI:10.2460/ajvr.69.1.89 — OMIA Phene_Article / Article\n- 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract — PubMed:PMID17608656 | DOI:10.1111/j.1748-5827.2007.00344.x — OMIA Phene_Article / Article\n- 2008. Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J — PubMed:PMID17317245 | DOI:10.1016/j.tvjl.2006.12.007 — OMIA Phene_Article / Article\n- 2006. Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci — PubMed:PMID17146188 — OMIA Phene_Article / Article\n- 2006. Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract — PubMed:PMID17004953 | DOI:10.1111/j.1748-5827.2006.00048.x — OMIA Phene_Article / Article\n- (46 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:186700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — French Bulldog — Syringomyelia (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"French Bulldog — Syringomyelia (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/5893238/","retrieved":"","ref":"PMID 5893238","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2679,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}