{"topic_id":"companion_breed_health_domestic_shorthair_omia1459_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_domestic_shorthair_omia1459_cat\ncategory: companion-breed-health\ntitle: \"Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/domestic_shorthair_omia1459_1459.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 221\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_domestic_shorthair_omia1459_cat/01_companion_breed_health_domestic_shorthair_omia1459_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000810/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Domestic Shorthair (Cat)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal dominant with incomplete penetrance`\n- `Clin feat: Polydactyly in cats is a congenital deformity, clinically characterized by the presence of more than 18 digits in total at birth, with the additional digit(s) on either their front and/or hind limb(s). A variety of combinations of different numbers of extra toes per paw have been observed, while the distribution of extra digits exhibits a non-continuous statistical pattern (Lange et al., 2013). Polydactyl cats not only have an unusual number and shape of digits, but they may also exhibit unharmful altered conformation of carpus and tarsus (Hamelin et al., 2016). IT thanks DVM student Ophelia Xinran Pan, who provided the basis of this contribution in May 2023.`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 28713538 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- Gene: Entrez Gene ID 389719890 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Polydactyly results from faults in the regulation of the developmental gene Sonic Hedgehog (SHH), which is expressed only at the border of the posterior limb bud, in a region called the zone of polarizing activity (ZPA). The faults in regulation result from mutations in an enhancer located in the LMBR1 gene, located about 1 MB upstream of SHH. The enhancer is called the ZPA regulatory sequence (ZR…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1961. The anatomy of polydactylism in cats with observations on genetic control. Anatomical Record — PubMed:PMID13878202 — OMIA Phene_Article / Article\n- 1964. On independent assortmant of dominant white and polydactyly in the cat. Journal of Cat Genetics — OMIA Phene_Article / Article\n- 1992. Polydactylism in a cat. Praktische Tierarzt — OMIA Phene_Article / Article\n- 1995. A case of atavistic polydactyly at the hind limb of a cat [German]. Kleintierpraxis — OMIA Phene_Article / Article\n- 1966. The independent assortment of dominant white and polydactyly in the cat. J Hered — PubMed:PMID5917255 — OMIA Phene_Article / Article\n- 2008. Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly. Hum Mol Genet — PubMed:PMID18156157 | DOI:10.1093/hmg/ddm370 — OMIA Phene_Article / Article\n- 1976. Mutant allele frequencies among domestic cats in some eastern areas of Canada: regional homogeneity of factors in Canadian Atlantic Provinces and the French colony of Saint Pierre. J Hered — PubMed:PMID1021595 — OMIA Phene_Article / Article\n- 2007. Hemingway's cats: to have or have not?. National Geographic — OMIA Phene_Article / Article\n- 1947. Heredity of polydactyly in the cat. J Hered — PubMed:PMID20242531 — OMIA Phene_Article / Article\n- 1947. Morphology of the feet in polydactyl cats. Am J Anat — PubMed:PMID20286212 — OMIA Phene_Article / Article\n- 1968. Polydactylism in cats. Vet Med Small Anim Clin — PubMed:PMID5188319 — OMIA Phene_Article / Article\n- 1902. Prepotency in polydactylous cats. Science — PubMed:PMID17833849 | DOI:10.1126/science.16.405.554 — OMIA Phene_Article / Article\n- (8 additional references in OMIA)\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:174500 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:605522 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:188740 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Domestic Shorthair — Polydactyly (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/13878202/","retrieved":"","ref":"PMID 13878202","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":1024,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}