{"topic_id":"companion_breed_health_devon_rex_devon_rex_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_devon_rex_devon_rex_cat\ncategory: companion-breed-health\ntitle: \"Devon Rex — Devon rex (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/devon_rex_devon_rex_3107.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 80\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_devon_rex_devon_rex_cat/01_companion_breed_health_devon_rex_devon_rex_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Devon Rex — Devon rex (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001581/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Devon Rex — Devon rex (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Devon Rex (Cat)`\n- `Disorder: Devon rex`\n- `Mode of inheritance: Autosomal recessive`\n- `Summary: see also a href=../../../../../../OMIA001712/9685/OMIA:001712-9685/a : Curly coat, Selkirk rex in Felis catus (domestic cat)`\n- `Defect: no`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 5778227 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Gandolfi et al. (2010) showed that the Devon rex mutation and the Sphynx hairless mutation (<a href=\"../../../../../../OMIA001583/9685/\">OMIA:001583-9685</a>) are both due to mutations in the KRT71 gene which encodes keratin 71: \"An 81-bp deletion (c.1108-4_1184del), including the last 4 bp of intron 6 and the first 77 bp of exon 7, followed by a 8-bp insertion (c.1184_1185insAGTTGGAG) and a base …\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 1969. Devon rex - a third rexoid coat mutant in the cat. Genetica — OMIA Phene_Article / Article\n- 2010. The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71. Mamm Genome — PubMed:PMID20953787 | DOI:10.1007/s00335-010-9290-6 — OMIA Phene_Article / Article\n- 2022. Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats. PLoS Genet — PubMed:PMID35709088 | DOI:10.1371/journal.pgen.1009804 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:608245 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:615896 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Devon Rex — Devon rex (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Devon Rex — Devon rex (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/20953787/","retrieved":"","ref":"PMID 20953787","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":624,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}