{"topic_id":"companion_breed_health_chihuahua_omia6682_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_chihuahua_omia6682_dog\ncategory: companion-breed-health\ntitle: \"Chihuahua — Ichthyosis, ALOXE3-related (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/chihuahua_omia6682_6682.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 204\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_chihuahua_omia6682_dog/01_companion_breed_health_chihuahua_omia6682_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Chihuahua — Ichthyosis, ALOXE3-related (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA003011/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Chihuahua — Ichthyosis, ALOXE3-related (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Chihuahua (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Probably autosomal recessive`\n- `Clin feat: Vinberg et al. (2025) investigated a Chihuahua with severe scaling since age 12 weeks. The scaling was generalized and involved the entire body and legs. The paw pads were mildly hyperkeratotic.`\n- `Defect: yes`\n- `Pathology: Vinberg et al. (2025) reported histopathological findings in skin biopsies of an affected Chihuahua which showed markedly increased amounts of keratin in the stratum corneum (marked lamellar orthokeratotic hyperkeratosis), with keratin lifting and flaking, explaining the clinical scaling ... . Mildly increased amounts of keratin in the infundibular hair follicle lumen were also observed (infundibular hyperkeratosis).`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 398299051 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Vinberg et al. (2025) \"sequenced the genome of the affected [Chihuahua] dog and compared the data to 1567 control genomes. Filtering for private variants identified a homozygous missense variant in&nbsp;<em>ALOXE3</em>, XP_038392720.1:p.(Gly460Asp). <em>ALOXE3</em> is a known candidate gene for ichthyosis in humans and encodes arachidonate epidermal lipoxygenase 3.\"\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2025. ALOXE3 missense variant in a Chihuahua with autosomal recessive ichthyosis. Anim Genet — PubMed:PMID41057024 | DOI:10.1111/age.70055 — OMIA Phene_Article / Article\n- 2026. Development of cost-effective PCR-RFLP methods for screening Mendelian disorders in Chihuahua dogs. F.U. Vet. J. Health Sci. — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:607206 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:606545 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Chihuahua — Ichthyosis, ALOXE3-related (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Chihuahua — Ichthyosis, ALOXE3-related (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/41057024/","retrieved":"","ref":"PMID 41057024","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":664,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}