{"topic_id":"companion_breed_health_border_collie_omia3393_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_border_collie_omia3393_dog\ncategory: companion-breed-health\ntitle: \"Border Collie — Deafness, adult-onset (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/border_collie_omia3393_3393.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 139\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_border_collie_omia3393_dog/01_companion_breed_health_border_collie_omia3393_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Border Collie — Deafness, adult-onset (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001727/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Border Collie — Deafness, adult-onset (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Border Collie (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal dominant`\n- `Clin feat: As reported by Yokoyama et al. (2012): the owners of the dogs included in this study estimated the age of onset of hearing loss based upon close observations of behavioral characteristics in working dogs indicating poor hearing (e.g., reduced call distance, poor performance). The average estimated age of onset was 4.3 years (S.E. of 0.5 years), with a range of 1–9 years.`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2012. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies.. PLoS Genet — PubMed:PMID23028339 | DOI:10.1371/journal.pgen.1002898 — OMIA Phene_Article / Article\n- 2014. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs.. Canine Genet Epidemiol — PubMed:PMID26401323 | DOI:10.1186/2052-6687-1-6 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2012. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet — PubMed:PMID23028339 | DOI:10.1371/journal.pgen.1002898 — OMIA Phene_Article / Article\n- 2014. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol — PubMed:PMID26401323 | DOI:10.1186/2052-6687-1-6 — OMIA Phene_Article / Article\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet — PubMed:PMID23028339 | DOI:10.1371/journal.pgen.1002898 — OMIA Phene_Article / Article\n- 2014. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol — PubMed:PMID26401323 | DOI:10.1186/2052-6687-1-6 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet — PubMed:PMID23028339 | DOI:10.1371/journal.pgen.1002898 — OMIA Phene_Article / Article\n- 2014. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol — PubMed:PMID26401323 | DOI:10.1186/2052-6687-1-6 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet — PubMed:PMID23028339 | DOI:10.1371/journal.pgen.1002898 — OMIA Phene_Article / Article\n- 2014. An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol — PubMed:PMID26401323 | DOI:10.1186/2052-6687-1-6 — OMIA Phene_Article / Article\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Border Collie — Deafness, adult-onset (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Border Collie — Deafness, adult-onset (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/23028339/","retrieved":"","ref":"PMID 23028339","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":965,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}