{"topic_id":"companion_breed_health_bashkir_curly_horse_omia6786_horse","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_bashkir_curly_horse_omia6786_horse\ncategory: companion-breed-health\ntitle: \"Bashkir Curly (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-23 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/bashkir_curly_horse_omia6786_6786.txt\ndate_parsed: 2026-08-23\ntokens_estimated: 151\nverification:\n method: substring_match\n claims: 5\n passed: 5\n date: 2026-08-23\nrecovered: false\npath: companion-breed-health/companion_breed_health_bashkir_curly_horse_omia6786_horse/01_companion_breed_health_bashkir_curly_horse_omia6786_horse.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n title: \"Bashkir Curly (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)\"\n url: \"https://omia.org/OMIA003039/9796/\"\n retrieved: \"2026-08-23\"\n ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n needs_review: false\n\nverification_derived:\n method: derived_from_dataset\n source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"---\n\n# Bashkir Curly (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Bashkir Curly (Horse)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal dominant`\n- `Summary: Morgenthaler et al. (2017): First described by Crow and Sioux Native American tribes as early as 1801 during winter horse counting [Thomas et al., 1989], Curly horses present a variety of coat curl phenotypes associated with diverse degrees of curliness which can range from “minimal” scattered curled hair up to extremely dense “micro curled” permanent coat as observed in certain Missouri Fox Trotter lines.nbsp;`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- Gene: Entrez Gene ID 388944862 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Morgenthaler et al. (2017): \"whole-genome sequences were obtained for one heterozygous curly stallion and its straight-haired son. Among the four non-synonymous candidate variants identified and validated in the curly region, only variant g.21891160G>A in the KRT25 gene (KRT25:p.R89H) [omia.variant:856] was in perfect agreement with haplotype status in the whole pedigree. Genetic assoc…\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- 1940. Inheritance of curliness in the horse. C.R. (Doklady) Academy of Science U.R.S.S., N.S. — OMIA Phene_Article / Article\n- 1990. Dominant Curly Coat in Horses. Genetics Selection Evolution — OMIA Phene_Article / Article\n- 2016. Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet — PubMed:PMID26662214 | DOI:10.1111/age.12393 — OMIA Phene_Article / Article\n- 2017. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse. Genet Sel Evol — PubMed:PMID29141579 | DOI:10.1186/s12711-017-0359-5 — OMIA Phene_Article / Article\n- 1989. Myth and mystery: the curly horse in America. New York: C.S. Fund Inc. — OMIA Phene_Article / Article\n- 1943. Curly coat of horses. Journal of Heredity — OMIA Phene_Article / Article\n- 2018. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep — PubMed:PMID29686323 | DOI:10.1038/s41598-018-24865-3 — OMIA Phene_Article / Article\n- 2024. Horse allergy: Curly Horses can mediate immune tolerance. Pneumologie — PubMed:PMID37827498 | DOI:10.1055/a-2101-9533 — OMIA Phene_Article / Article\n- 2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/.txt source file.\n- OMIM:616760 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:616646 (type: gene) — OMIA Group_OMIM (via OMIA_ID)\n","sources":["companion-breed-health — Bashkir Curly (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Bashkir Curly (Horse) — Curly coat, KRT25-related (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/26662214/","retrieved":"","ref":"PMID 26662214","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":848,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}