{"topic_id":"companion_breed_health_american_staffordshire_terrier_omia4296_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_american_staffordshire_terrier_omia4296_dog\ncategory: companion-breed-health\ntitle: \"American Staffordshire Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/american_staffordshire_terrier_omia4296_4296.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 84\nverification:\n  method: substring_match\n  claims: 4\n  passed: 4\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_american_staffordshire_terrier_omia4296_dog/01_companion_breed_health_american_staffordshire_terrier_omia4296_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"American Staffordshire Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA002245/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# American Staffordshire Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: American Staffordshire Terrier (Dog)`\n- `Disorder: `\n- `Clin feat: Letko et a. (2020): persistent and sharp pain when opening mouth, painful swelling of the jaw, fever, and in some cases also severe pain of ulna and radius bones.`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIA entry symbol: CHS (no structured Phene_Gene link)\n- OMIA molecular-genetics note: Letko et al. (2020) whole-genome sequenced an affected American Staffordshire Terrier but were not able to identify a likely causal variant.\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2012. Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. Vet Ophthalmol — PubMed:PMID22192474 | DOI:10.1111/j.1463-5224.2011.00969.x — OMIA Phene_Article / Article\n- 2011. Idiopathic canine juvenile cranial hyperostosis in a Pit Bull Terrier. N Z Vet J — PubMed:PMID21660851 | DOI:10.1080/00480169.2011.579556 — OMIA Phene_Article / Article\n- 2020. Whole genome sequencing indicates heterogeneity of hyperostotic disorders in dogs. Genes (Basel) — PubMed:PMID32033218 | DOI:10.3390/genes11020163 — OMIA Phene_Article / Article\n- 2000. Idiopathic hyperostosis of the calvaria in five young bullmastiffs. J Am Anim Hosp Assoc — PubMed:PMID10997521 | DOI:10.5326/15473317-36-5-439 — OMIA Phene_Article / Article\n- 2006. Calvarial hyperostosis syndrome in two bullmastiffs. Vet Radiol Ultrasound — PubMed:PMID16429988 | DOI:10.1111/j.1740-8261.2005.00108.x — OMIA Phene_Article / Article\n- 2015. Calvarial hyperostosis syndrome in a young Weimaraner dog. Vlaams Diergeneeskundig Tijdschrift — OMIA Phene_Article / Article\n- 2025. Suspected calvarial hyperostosis syndrome causing different ophthalmological signs in two young Labrador Retrievers-Case report. Vet Ophthalmol — PubMed:PMID39988334 | DOI:10.1111/vop.70007 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:302030 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — American Staffordshire Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"American Staffordshire Terrier — Calvarial hyperostotic syndrome (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/22192474/","retrieved":"","ref":"PMID 22192474","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":690,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}